Lerner U H, Sahlberg K, Ljunggren O
Department of Oral Pathology, University of Umeå, Sweden.
J Oral Pathol Med. 1989 Apr;18(4):246-50. doi: 10.1111/j.1600-0714.1989.tb00772.x.
Thrombin and bradykinin stimulate production of prostaglandin E2 (PGE2), and 6-keto-prostaglandin F1 alpha (the stable breakdown product of prostacyclin) in isolated human peripheral blood monocytes in a dose- and time-dependent manner. Since PGE2 and prostacyclin can affect the activity of immunocompetent cells and bone resorbing osteoclasts, our finding indicates that thrombin and bradykinin, both of which are formed in inflammatory processes as a consequence of activation of the Hageman factor (coagulation factor XII), may have important roles in the modulation of the inflammatory response and the loss of alveolar bone in periodontitis.
凝血酶和缓激肽能以剂量和时间依赖的方式刺激人外周血单个核细胞产生前列腺素E2（PGE2）和6-酮-前列腺素F1α（前列环素的稳定降解产物）。由于PGE2和前列环素能够影响免疫活性细胞和骨吸收破骨细胞的活性，我们的研究结果表明，凝血酶和缓激肽均在炎症过程中因Hageman因子（凝血因子XII）激活而形成，它们可能在牙周炎炎症反应调节和牙槽骨丧失中发挥重要作用。
