Fujita Y, Sugawa C, Masuyama H, Lucas C E
Nihon Shokakibyo Gakkai Zasshi. 1989 Mar;86(3):725-30.
The relative value of a subserosal injection of 98% ethanol (0.2 ml x 4) in controlling acute and chronic bleeding from serosal vessels was assessed in dogs. Blood flow was measured from gastric serosal vessels (average diameter 1.6 mm) severed immediately after, 24 hours after, and 48 hours after ethanol injection. Blood flow from severed colonic serosal vessels (averaging diameter 1.0 mm) was measured prior to and immediately after ethanol injection. The safety of ethanol injection was tested by endoscopically guided submucosal injection which were sequentially observed endoscopy at one hour, 24 hours, and weekly for weeks after injection. Ethanol injection had no effect on bleeding from larger gastric vessels unless the injection was made 24 or 48 hours prior to vessel severence. Ethanol injection was effective in reducing bleeding from the smaller colonic vessels when done immediately prior to vessel severence. Gastric submucosal injections led to ulcers which extended into the muscle layer at on week and healed completely by three weeks; none perforated or bleed. These data support the potential efficacy of therapeutic ethanol injection for the control of small vessel (1.0 mm diameter) bleeding and the potential prophylactic value against rebleeding from larger vessels. Further studies are needed to determine if these findings are organ related as opposed to being diameter specific.
评估了在犬体内经浆膜下注射98%乙醇（0.2毫升×4次）控制浆膜血管急性和慢性出血的相对价值。在乙醇注射后即刻、24小时后和48小时后，测量切断的胃浆膜血管（平均直径1.6毫米）的血流。在乙醇注射前和注射后即刻，测量切断的结肠浆膜血管（平均直径1.0毫米）的血流。通过内镜引导下黏膜下注射来测试乙醇注射的安全性，注射后1小时、24小时以及之后数周每周进行内镜观察。除非在切断血管前24或48小时进行注射，乙醇注射对较大胃血管的出血没有影响。在切断结肠血管前即刻进行乙醇注射，可有效减少较小结肠血管的出血。胃黏膜下注射导致溃疡，一周时溃疡扩展至肌层，三周时完全愈合；无穿孔或出血情况。这些数据支持治疗性乙醇注射控制小血管（直径1.0毫米）出血的潜在疗效以及预防较大血管再出血的潜在价值。需要进一步研究以确定这些发现是与器官相关还是仅与血管直径相关。
