Liu Changjing, Huang Fei, Yang Zhizhou, Sun Zhaorui, Huang Changbao, Liu Hongmei, Shao Danbing, Zhang Wei, Ren Yi, Tang Wenjie, Han Xiaoqin, Nie Shinan
Department of Emergency Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
Department of Emergency Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China; Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Aug;36(8):889-95.
To analyze the associations between air pollution and adverse health outcomes on respiratory diseases and to estimate the short-term effects of air pollutions [Particulate matter with particle size below 10 microns (PM(10)), PM(10) particulate matter with particle size below 2.5 microns (PM(2.5)), nitrogen dioxide (NO₂), sulphur dioxide (SO₂) and ozone (O₃)] on respiratory mortality in China.
Data related to the epidemiological studies on the associations between air pollution and adverse health outcomes of respiratory diseases that published from 1989 through 2014 in China, were collected by systematically searching databases of PubMed, SpringerLink, Embase, Medline, CNKI, CBM and VIP in different provinces of China. Short-term effects between (PM(10), PM(2.5), NO₂, SO₂, O₃) and respiratory mortality were analyzed by Meta-analysis method, and estimations were pooled by random or fixed effect models, using the Stata 12.0 software.
A total of 157 papers related to the associations between air pollution and adverse health outcomes of respiratory diseases in China were published, which covered 79.4% of all the provinces in China. Results from the Meta-analysis showed that a 10 µg/m³ increase in PM10, PM(2.5), NO₂, SO₂, and O₃was associated with mortality rates as 0.50% (95% CI: 0-0.90%), 0.50% (95% CI: 0.30%-0.70%), 1.39% (95% CI: 0.90%-1.78%), 1.00% (95% CI: 0.40%-1.59%) and 0.10% (95% CI: -1.21%-1.39%) in respiratory tracts, respectively. No publication bias was found among these studies.
There seemed positive associations existed between PM(10)/PM(2.5)/NO₂/SO₂and respiratory mortality in China that the relationship called for further attention on air pollution and adverse health outcomes of the respiratory diseases.
分析空气污染与呼吸系统疾病不良健康结局之间的关联，并估算空气污染[粒径小于10微米的颗粒物（PM₁₀）、粒径小于2.5微米的PM₁₀颗粒物（PM₂.₅）、二氧化氮（NO₂）、二氧化硫（SO₂）和臭氧（O₃）]对中国呼吸系统死亡率的短期影响。
通过系统检索中国不同省份的PubMed、SpringerLink、Embase、Medline、CNKI、CBM和VIP数据库，收集1989年至2014年期间发表的关于空气污染与呼吸系统疾病不良健康结局之间关联的流行病学研究数据。采用Meta分析方法分析（PM₁₀、PM₂.₅、NO₂、SO₂、O₃）与呼吸系统死亡率之间的短期影响，并使用Stata 12.0软件通过随机或固定效应模型进行汇总估计。
共发表了157篇关于中国空气污染与呼吸系统疾病不良健康结局之间关联的论文，覆盖了中国所有省份的79.4%。Meta分析结果显示，PM₁₀、PM₂.₅、NO₂、SO₂和O₃每增加10μg/m³，呼吸道死亡率分别为0.50%（95%CI：0 - 0.90%）、0.50%（95%CI：0.30% - 0.70%）、1.39%（95%CI：0.90% - 1.78%）、1.00%（95%CI：0.40% - 1.59%）和0.10%（95%CI： - 1.21% - 1.39%）。这些研究中未发现发表偏倚。
在中国，PM₁₀/PM₂.₅/NO₂/SO₂与呼吸系统死亡率之间似乎存在正相关，这种关系需要进一步关注空气污染和呼吸系统疾病的不良健康结局。
