Shen Huijie, Shao Sheng, Zhang Jinglu, Wang Zhendong, Lv Dong, Chen Wenjing, Svensson Peter, Wang Kelun
Orofacial Pain and TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Institute of Stomatology and Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Eur J Oral Sci. 2016 Feb;124(1):26-32. doi: 10.1111/eos.12234. Epub 2015 Dec 30.
This study aimed to assess the short-term effects of orthodontic pain on quantitative sensory testing (QST) in subjects receiving fixed orthodontic treatment. Twenty patients and 12 healthy volunteers (as controls) participated. All 20 patients had bonded AO self-ligating brackets, with a 0.014 super elastic nickel-titanium arch wire placed in the brackets. Pain [self-reported on a visual analog scale (VAS)], and thermal and mechanical thresholds, were tested at six time points--before (baseline), and 2 h, 24 h, 7 d, 14 d, and 30 d after, force application--in the treatment group. The attached gingiva adjacent to the left upper central incisor (21 gingiva) was hypersensitive to cold stimuli (i.e. increased cold detection thresholds were detected) in the treatment group. The pressure pain thresholds of the left upper central incisor (21) and 21 gingiva were significantly reduced. Our results suggest clear signs of sensitization of the trigeminal nociceptive system up to 1 month after force application and orthodontic pain. Quantitative assessment of somatosensory function may help to provide a better understanding and profiling of the underlying neurobiological mechanisms related to orthodontic pain.
本研究旨在评估接受固定正畸治疗的受试者正畸疼痛对定量感觉测试（QST）的短期影响。20名患者和12名健康志愿者（作为对照）参与了研究。所有20名患者均粘结了AO自结扎托槽，并在托槽中放置了0.014的超弹性镍钛弓丝。在治疗组中，于施加力前（基线）以及施加力后2小时、24小时、7天、14天和30天这六个时间点测试疼痛[通过视觉模拟量表（VAS）自我报告]以及热阈值和机械阈值。治疗组中，左上中切牙（21号牙牙龈）附近的附着龈对冷刺激敏感（即检测到冷觉阈值升高）。左上中切牙（21号牙）和21号牙牙龈的压痛阈值显著降低。我们的结果表明，在施加力和正畸疼痛后长达1个月的时间里，三叉神经伤害感受系统有明显的敏化迹象。躯体感觉功能的定量评估可能有助于更好地理解和描述与正畸疼痛相关的潜在神经生物学机制。
