乙型和丙型肝炎病毒感染与胰腺癌风险：一项基于人群的队列研究（日本公共卫生中心队列研究II）
Hepatitis B and C Virus Infection and Risk of Pancreatic Cancer: A Population-Based Cohort Study (JPHC Study Cohort II).
作者信息
Krull Abe Sarah, Inoue Manami, Sawada Norie, Iwasaki Motoki, Shimazu Taichi, Yamaji Taiki, Sasazuki Shizuka, Saito Eiko, Tanaka Yasuhito, Mizokami Masashi, Tsugane Shoichiro
机构信息
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
出版信息
Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):555-7. doi: 10.1158/1055-9965.EPI-15-1115. Epub 2015 Dec 29.
BACKGROUND
The aim of this study was to assess the association between hepatitis B virus (HBV) and hepatitis C virus (HCV) and the risk of pancreatic cancer among Japanese adults.
METHODS
A total of 20,360 subjects of the Japan Public Health Center (JPHC)-based prospective study cohort II with available data on HBV and HCV infection status from blood samples were followed up until the end of 2010 for an average of 16 years. Cox proportional hazards models were employed to calculate HRs and 95% confidence intervals (CI).
RESULTS
During 324,394 person-years, 116 newly diagnosed cases of pancreatic cancer were identified. Compared with individuals without a positive infection marker, the multivariate-adjusted HRs were 1.22 (95% CI, 0.81-1.84) for anti-HBc and 0.69 (95% CI, 0.28-1.69) for anti-HCV. There were no pancreatic cancer cases among HBsAg-positive participants.
CONCLUSION
In the JPHC study, we did not observe a statistically significant association between hepatitis B or C and the risk of pancreatic cancer.
IMPACT
Our results do not support an association between hepatitis B or C and the risk of pancreatic cancer.
背景
本研究旨在评估日本成年人中乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）与胰腺癌风险之间的关联。
方法
日本公共卫生中心（JPHC）前瞻性研究队列II中共有20360名受试者，其血液样本中有关于HBV和HCV感染状况的可用数据，随访至2010年底，平均随访16年。采用Cox比例风险模型计算风险比（HRs）和95%置信区间（CI）。
结果
在324394人年期间，共确诊116例胰腺癌新发病例。与无阳性感染标志物的个体相比，抗-HBc的多因素调整后HR为1.22（95%CI，0.81-1.84），抗-HCV的多因素调整后HR为0.69（95%CI，0.28-1.69）。HBsAg阳性参与者中未出现胰腺癌病例。
结论
在JPHC研究中，我们未观察到乙型或丙型肝炎与胰腺癌风险之间存在统计学显著关联。
影响
我们的结果不支持乙型或丙型肝炎与胰腺癌风险之间存在关联。
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