乙型肝炎或丙型肝炎病毒感染与胰腺癌风险之间的关联：队列研究的系统评价和荟萃分析
Association between hepatitis B or hepatitis C virus infection and risk of pancreatic cancer: a systematic review and meta-analysis of cohort studies.
作者信息
Zhao Jian-Feng, Teng Qiu-Ping, Lv Yang, Li Xiao-Yi, Ding Yi
机构信息
Department of Gastrointestinal Surgery, Jingmen People's Hospital, Jingchu University of Technology Affiliated Central Hospital, Jingmen, Hubei Province, China.
Central Hospital, Jingmen, Hubei Province, China.
出版信息
Ther Adv Infect Dis. 2023 Nov 8;10:20499361231212161. doi: 10.1177/20499361231212161. eCollection 2023 Jan-Dec.
BACKGROUND AND AIM
With conflicting data from previous observational studies on the relationship between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and pancreatic cancer (PC), we decided to conduct a systematic review and meta-analysis in order to evaluate any potential association.
DESIGN
This is a systematic review and meta-analysis.
METHODS
We conducted a search of three databases (PubMed, Embase, and Web of Science) from the time of their creation up to June 2023. The summary results, including hazard ratio (HR) with 95% confidence interval (CI), were pooled using a generic inverse variance method and a random-effects model. Furthermore, subgroup and sensitivity analyses were conducted.
RESULTS
In this meta-analysis, 22 cohort studies with a total of 10,572,865 participants were analyzed. Meta-analysis from 15 cohort studies revealed that HBV infection was correlated with an increased risk of PC (HR = 1.53, 95% CI: 1.40-1.68, < 0.00001) with no heterogeneity ( = 0%, = 0.49). Meta-analysis from 14 cohort studies showed that HCV infection was associated with an increased risk of PC (HR = 1.82, 95% CI: 1.51-2.21, < 0.00001). Most of our subgroup analyses yielded similar results. Meta-analysis from four cohort studies indicated that co-infection with HBV and HCV was linked to an increased risk of PC (HR = 2.32, 95% CI: 1.40-3.85, = 0.001) with no heterogeneity observed ( = 0%, = 0.60). The results of sensitivity analyses were robust.
CONCLUSION
Our meta-analysis showed that HBV/HCV infection or co-infection with HBV and HCV was associated with an increased risk of PC. Future prospective cohort studies need to take into account various ethnicities and any confounding factors, as well as investigate the potential mechanisms of PC development in those with HBV/HCV.
TRIAL REGISTRATION
Open Science Framework registries (No: osf.io/n64ua).
背景与目的
既往关于乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）感染与胰腺癌（PC）之间关系的观察性研究数据相互矛盾，我们决定进行一项系统评价和荟萃分析，以评估任何潜在关联。
设计
这是一项系统评价和荟萃分析。
方法
我们检索了三个数据库（PubMed、Embase和Web of Science），检索时间从其创建至2023年6月。汇总结果，包括风险比（HR）及其95%置信区间（CI），采用通用逆方差法和随机效应模型进行合并。此外，还进行了亚组分析和敏感性分析。
结果
在这项荟萃分析中，分析了22项队列研究，共有10572865名参与者。15项队列研究的荟萃分析显示，HBV感染与PC风险增加相关（HR = 1.53，95%CI：1.40 - 1.68，P < 0.00001），无异质性（I² = 0%，P = 0.49）。14项队列研究的荟萃分析表明，HCV感染与PC风险增加有关（HR = 1.82，95%CI：1.51 - 2.21，P < 0.00001）。我们的大多数亚组分析得出了类似的结果。四项队列研究的荟萃分析表明，HBV和HCV合并感染与PC风险增加有关（HR = 2.32，95%CI：1.40 - 3.85，P = 0.001），未观察到异质性（I² = 0%，P = 0.60）。敏感性分析结果稳健。
结论
我们的荟萃分析表明，HBV/HCV感染或HBV与HCV合并感染与PC风险增加有关。未来的前瞻性队列研究需要考虑各种种族和任何混杂因素，并研究HBV/HCV感染者PC发生的潜在机制。
试验注册
开放科学框架注册库（编号：osf.io/n64ua）。
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