Zuccaro L, Cox A, Pray C, Radford K, Novakowski K, Dorrington M, Surette M G, Bowdish D, Nair P
Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Allergy. 2016 Apr;71(4):571-5. doi: 10.1111/all.12831. Epub 2016 Jan 25.
An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity.
