Sagah Ghada A, Oreby Merfat M, El-Gharbawy Rehab M, Ahmed Fathy Amal S
Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Int J Health Sci (Qassim). 2015 Oct;9(4):375-85.
To evaluate potential oxidative stress in patients with acute phosphide poisoning and the effect of vitamin C.
Participants were females and divided into three groups; group I: healthy volunteers group II: healthy volunteers received vitamin C, group III: patients with acute phosphide poisoning received the supportive and symptomatic treatment and group IV: patients with acute phosphide poisoning received the supportive and symptomatic treatment in addition to vitamin C. All the participants were subjected to thorough history, clinical examination, ECG and laboratory investigations were carried on collected blood and gastric lavage samples on admission. Blood samples were divided into two parts, one for measurement of routine investigations and the second part was used for evaluation of malondialdehyde and total thiol levels before and after receiving the treatment regimen.
Most of the cases in this study were among the age group of 15-25 years, females, single, secondary school education, from rural areas and suicidal. All vital signs were within normal range and the most common complaint was vomiting and abdominal pain. All cases in this study showed normal routine investigations. The mean MDA levels after receiving treatment decreased significantly in groups II and IV. The mean total thiol levels increased significantly after receiving treatment in groups II and IV.
It can be concluded that vitamin C has a potential benefit due to its antioxidant property on zinc phosphide induced-oxidative stress in acute zinc phosphide poisoned patients.
评估急性磷化锌中毒患者潜在的氧化应激情况以及维生素C的作用。
参与者为女性，分为四组；第一组：健康志愿者；第二组：接受维生素C的健康志愿者；第三组：接受支持性和对症治疗的急性磷化锌中毒患者；第四组：除接受支持性和对症治疗外还接受维生素C的急性磷化锌中毒患者。所有参与者均接受详细病史询问、临床检查、心电图检查，并在入院时对采集的血液和洗胃样本进行实验室检查。血液样本分为两部分，一部分用于常规检查，另一部分用于评估治疗方案前后丙二醛和总巯基水平。
本研究中的大多数病例为15至25岁年龄组，女性，单身，中学文化程度，来自农村地区且有自杀倾向。所有生命体征均在正常范围内，最常见的主诉是呕吐和腹痛。本研究中的所有病例常规检查均正常。第二组和第四组接受治疗后丙二醛平均水平显著降低。第二组和第四组接受治疗后总巯基平均水平显著升高。
可以得出结论，由于维生素C具有抗氧化特性，它对急性磷化锌中毒患者因磷化锌诱导的氧化应激具有潜在益处。
