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在无嗜酸性粒细胞增多的难治性慢性粒-单核细胞白血病中检测到血小板衍生生长因子受体B（PDGFRB）融合基因：广谱肿瘤分析的一个实例

Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling.

作者信息

Bell Gillian C, Padron Eric

机构信息

DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer and Research Institute, Tampa, FL, United States ; Department of Population Sciences, H. Lee Moffitt Cancer and Research Institute, Tampa, FL, United States.

Department of Hematologic Malignancies and Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States.

出版信息

Leuk Res Rep. 2015 Sep 24;4(2):70-1. doi: 10.1016/j.lrr.2015.07.002. eCollection 2015.

DOI:10.1016/j.lrr.2015.07.002
PMID:26716078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4672079/
Abstract

In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling in refractory CMML cases as an opportunity to uncover additional treatment options.

摘要

在本病例报告中，我们描述了一例无嗜酸性粒细胞增多的难治性慢性粒-单核细胞白血病（CMML）病例，该病例存在血小板衍生生长因子受体B（PDGFRB）重排，对伊马替尼治疗产生了良好反应。我们认为，该病例证明了在难治性CMML病例中进行广谱基因组分析的实用性，这是发现其他治疗选择的一个契机。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5939/4672079/b731433fa5e5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5939/4672079/b731433fa5e5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5939/4672079/b731433fa5e5/gr1.jpg

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