Keur I, Krediet R T, Arisz L
Neth J Med. 1989 Jun;34(5-6):270-84.
A review is presented of the association between a glomerular disease and a malignancy. The incidence of Hodgkin's disease in patients with glomerulopathy is very low, but the incidence of a solid tumour in a patient with glomerulopathy varies between 3 and 13%, mean 7%, and may be as high as 22% in patients over 60 years of age with a membranous nephropathy. A solid tumour was found most frequently in patients with membranous nephropathy. On the other hand, minimal change nephropathy is often associated with Hodgkin's disease and membrano-proliferative glomerulopathy with chronic lymphatic leukaemia. In Hodgkin's disease-associated glomerulopathy, a defect in the function of T lymphocytes is probably important, but the precise pathogenesis has not yet been elucidated. The other glomerulopathies may be mediated by immune complexes, containing tumour-derived antigens and their antibodies, either formed in situ or deposited as complexes from the circulation.
本文综述了肾小球疾病与恶性肿瘤之间的关联。肾小球病患者中霍奇金病的发病率很低，但肾小球病患者实体瘤的发病率在3%至13%之间，平均为7%，60岁以上的膜性肾病患者中可能高达22%。实体瘤在膜性肾病患者中最为常见。另一方面，微小病变肾病常与霍奇金病相关，膜增生性肾小球病常与慢性淋巴细胞白血病相关。在霍奇金病相关的肾小球病中，T淋巴细胞功能缺陷可能很重要，但确切的发病机制尚未阐明。其他肾小球病可能由免疫复合物介导，这些免疫复合物含有肿瘤衍生抗原及其抗体，它们要么在原位形成，要么作为循环中的复合物沉积。
