Lerrer Batia, Gertler Asaf A, Cohen Haim Y
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
Carcinogenesis. 2016 Feb;37(2):108-18. doi: 10.1093/carcin/bgv167. Epub 2015 Dec 30.
SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD(+)-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.
SIRT6是哺乳动物沉默调节蛋白家族的成员之一，作为单ADP核糖基转移酶以及乙酰基和长链脂肪酰基的NAD(+)依赖性脱酰基酶发挥作用。SIRT6调节多种细胞功能，如转录、基因组稳定性、端粒完整性、DNA修复、炎症以及糖尿病、肥胖症和癌症等与代谢相关的疾病。在这篇综述中，我们将讨论SIRT6在癌症生物学中的意义以及与机体稳态和寿命的相关性。
