Al-Qattan Mohammad M, Arafah Maha M
Division of Plastic and Hand Surgery, King Saud University, Riyadh, Saudi Arabia; Department of Pathology, King Saud University, Riyadh, Saudi Arabia.
Division of Plastic and Hand Surgery, King Saud University, Riyadh, Saudi Arabia; Department of Pathology, King Saud University, Riyadh, Saudi Arabia.
J Hand Surg Am. 2016 Feb;41(2):251-6. doi: 10.1016/j.jhsa.2015.11.011. Epub 2015 Dec 22.
The adult counterpart of infantile myofibromatosis is rare and is known as myofibroma. Cases are rare, and previous ones have been reported as isolated case reports; hence, there has been no consensus regarding the clinical presentation, surgical reconstruction, histological features, and recurrence of hand myofibromas. Over a 10-year period, the senior author treated 6 patients. We review our cases as well as 6 previously reported cases. The presentation is usually a single hand mass in a young adult. The tumor may arise from the lower dermis or from deeper fibrous structures of the hand including the palmar fascia. Tumors that arise from the dermis are best treated by skin excision to ensure complete excision. Histologically, the tumor is composed of highly cellular myofibroblast proliferation and is strongly positive to smooth muscle actin immune stain. The recurrence rate after excision is low.
婴儿肌纤维瘤病的成人对应疾病较为罕见，称为肌纤维瘤。病例罕见，以往的病例均为个案报道；因此，关于手部肌纤维瘤的临床表现、手术重建、组织学特征及复发情况尚无共识。在10年期间，资深作者治疗了6例患者。我们回顾了我们的病例以及6例先前报道的病例。表现通常为年轻成人手部的单个肿块。肿瘤可能起源于真皮下层或手部更深层的纤维结构，包括掌腱膜。起源于真皮的肿瘤最好通过皮肤切除来确保完整切除。组织学上，肿瘤由高度细胞性的肌成纤维细胞增殖组成，对平滑肌肌动蛋白免疫染色呈强阳性。切除后的复发率较低。
