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Virology. 2015 Sep;483:253-63. doi: 10.1016/j.virol.2015.04.016. Epub 2015 May 19.
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Naturally Occurring Capsid Protein Variants of Human Papillomavirus Genotype 31 Represent a Single L1 Serotype.人乳头瘤病毒31型的天然衣壳蛋白变体代表单一L1血清型。
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J Virol. 2015 Jan 15;89(2):1428-38. doi: 10.1128/JVI.02898-14. Epub 2014 Nov 12.
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Lineages of oncogenic human papillomavirus types other than type 16 and 18 and risk for cervical intraepithelial neoplasia.除16型和18型以外的致癌性人乳头瘤病毒谱系与宫颈上皮内瘤变风险
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人乳头瘤病毒45型（HPV45）天然存在的主要和次要衣壳蛋白变体：HPV疫苗产生的交叉中和抗体的差异识别

Naturally Occurring Major and Minor Capsid Protein Variants of Human Papillomavirus 45 (HPV45): Differential Recognition by Cross-Neutralizing Antibodies Generated by HPV Vaccines.

作者信息

Godi Anna, Facchetti Alessandra, Bissett Sara L, Cocuzza Clementina, Miller Elizabeth, Beddows Simon

机构信息

Virus Reference Department, Public Health England, London, United Kingdom.

Virus Reference Department, Public Health England, London, United Kingdom Department of Surgery and Translational Medicine, University of Milan-Bicocca, Monza, Italy.

出版信息

J Virol. 2015 Dec 30;90(6):3247-52. doi: 10.1128/JVI.02859-15.

DOI:10.1128/JVI.02859-15
PMID:26719255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4810639/
Abstract

We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle-to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.

摘要

我们研究了人乳头瘤病毒45型（HPV45）主要衣壳蛋白（L1）和次要衣壳蛋白（L2）的自然发生变异。代表HPV45亚系A1、A2、A3、B1和B2的假病毒（PsV）表现出相当的颗粒感染率和形态，但与A1亚系相比，对HPV疫苗抗体交叉中和的敏感性既有增加（A2、A3和B1）的情况，也有降低（B2）的情况。突变假病毒确定HI环残基357是赋予这种差异敏感性的关键因素。