Shen Jiucheng, Wang Mei, Wang Xiaodan, Zhang Guanbai, Guo Jie, Li Xinyue, Li Jianhua
Yunnan Institute for Drug Abuse, Kunming, China (JS, XW, GZ, JG, XL, JL); National Addiction Centre, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College, London, UK (MW).
J Addict Med. 2016 Jan-Feb;10(1):40-5. doi: 10.1097/ADM.0000000000000180.
China initiated the methadone maintenance treatment (MMT) program since 2004. The main challenge has been poor clinic adherence, which has a serious impact on treatment efficacy.
The aim of the study was to identify predictors of poor adherence to MMT in Yunnan Province, China.
We performed a case-control study of 764 patients, newly enrolled or re-enrolled on MMT programs, between January 1, 2007 and December 31, 2011. Information was obtained from clinic databases.
The frequency of poor adherence was 561 (73.43%). Lower daily methadone dosage (<60 mg) was significantly associated with poor adherence (odds ratio 4.07; 95% confidence interval, 2.88-5.74; P value < 0.001). Younger age was also a significant predictor of poor adherence (odds ratio 1.04; 95% confidence interval, 1.01-1.05; P value < 0.01).
Higher dosage of methadone is recommended as a way to improve treatment adherence.
中国自2004年起启动美沙酮维持治疗（MMT）项目。主要挑战在于诊所依从性差，这对治疗效果有严重影响。
本研究旨在确定中国云南省美沙酮维持治疗依从性差的预测因素。
我们对2007年1月1日至2011年12月31日期间新加入或重新加入美沙酮维持治疗项目的764名患者进行了病例对照研究。信息来自诊所数据库。
依从性差的发生率为561例（73.43%）。每日美沙酮剂量较低（<60毫克）与依从性差显著相关（比值比4.07；95%置信区间，2.88 - 5.74；P值<0.001）。年龄较小也是依从性差的一个显著预测因素（比值比1.04；95%置信区间，1.01 - 1.05；P值<0.01）。
建议增加美沙酮剂量以提高治疗依从性。
