Minami M, Itai Y, Ohtomo K, Ohnishi S, Niki T, Kokubo T, Yoshikawa K, Iio M
Department of Radiology, University of Tokyo Hospital, Japan.
Radiology. 1989 Sep;172(3):681-4. doi: 10.1148/radiology.172.3.2672092.
The authors retrospectively evaluated magnetic resonance (MR) images obtained at 1.5 T in 233 patients with portal hypertension and 91 subjects without it and pathologic findings in four resected spleens (one normal). Multiple, tiny (3-8 mm in diameter), low-intensity spots in the spleen were observed in 21 of 233 patients. Among the imaging studies performed in these 21 patients, the spots were seen on five of 14 T1-weighted images, 11 of 20 proton density images, and 12 of 20 T2-weighted images obtained with spin-echo techniques and on 14 of 14 fast-scan images obtained with gradient-echo rephasing. MR images in the 91 subjects did not show such lesions. MR images of the three spleens resected from patients with portal hypertension showed the low-intensity spots, which corresponded to siderotic nodules found at pathologic analysis. Despite limited pathologic confirmation, siderotic nodules (so-called Gamna-Gandy nodules) are considered the most likely cause of multiple low-intensity spots in the spleen.
作者回顾性评估了233例门静脉高压患者和91例非门静脉高压受试者在1.5T磁场下获得的磁共振（MR）图像，以及4个切除脾脏（1个正常）的病理结果。在233例患者中，有21例在脾脏中观察到多个微小（直径3-8mm）的低强度斑点。在对这21例患者进行的影像学检查中，在14幅T1加权图像中的5幅、20幅质子密度图像中的11幅、采用自旋回波技术获得的20幅T2加权图像中的12幅以及采用梯度回波重相位技术获得的14幅快速扫描图像中均可见到这些斑点。91例受试者的MR图像未显示此类病变。从门静脉高压患者切除的3个脾脏的MR图像显示出低强度斑点，病理分析发现这些斑点对应于含铁血黄素沉着结节。尽管病理证实有限，但含铁血黄素沉着结节（所谓的Gamna-Gandy结节）被认为是脾脏中多个低强度斑点的最可能原因。
