Ouyang Huang-Qing, Gong Zuo-Jiong, Zha Yun-Fei, Liu Chang-Sheng, Yang Zhao-Hui
Departments of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Exp Ther Med. 2013 Aug;6(2):445-450. doi: 10.3892/etm.2013.1135. Epub 2013 May 31.
The aim of this study was to investigate the interrelation between splenic siderotic nodules, hypersplenism and liver function in patients with liver cirrhosis. The splenic enhanced susceptibility-weighted angiography (ESWAN) and conventional magnetic resonance images of 33 patients with liver cirrhosis were retrospectively studied and the ESWAN images were graded. The distribution and prevalence of the image grades for patients with and without hypersplenism were evaluated. In addition, the splenic volume and the distribution of Child-Pugh and albumin scores were compared between patients with and without siderotic nodules, and the correlation between splenic volume and the ESWAN image grades were evaluated in the patients with siderotic nodules. The ESWAN images revealed splenic siderotic nodules in 24 patients. The distribution and prevalence of the ESWAN image grades were demonstrated to be significantly different (P<0.001) between patients with and without hypersplenism. Furthermore, significant differences were observed between patients with and without siderotic nodules with regard to splenic volume and the distribution of Child-Pugh and serum albumin scores (P<0.001). No significant correlation was demonstrated between splenic volume and the ESWAN image grades (P>0.05). In conclusion, a higher prevalence of splenic siderotic nodules (72.7%) was observed using the ESWAN sequence, in comparison with results from previous studies, obtained using the T1-spoiled gradient echo sequence. The presence of splenic siderotic nodules was consistent with the occurrence of hypersplenism and was interrelated with reserved liver function.
本研究旨在探讨肝硬化患者脾铁质沉着结节、脾功能亢进与肝功能之间的相互关系。回顾性研究了33例肝硬化患者的脾脏增强磁共振血管造影（ESWAN）及常规磁共振图像，并对ESWAN图像进行分级。评估有无脾功能亢进患者图像分级的分布及发生率。此外，比较有无铁质沉着结节患者的脾脏体积以及Child-Pugh评分和白蛋白评分的分布情况，并评估有铁质沉着结节患者的脾脏体积与ESWAN图像分级之间的相关性。ESWAN图像显示24例患者存在脾铁质沉着结节。有无脾功能亢进患者的ESWAN图像分级分布及发生率差异有统计学意义（P<0.001）。此外，有无铁质沉着结节患者在脾脏体积、Child-Pugh评分分布及血清白蛋白评分方面差异有统计学意义（P<0.001）。脾脏体积与ESWAN图像分级之间未显示出显著相关性（P>0.05）。总之，与之前使用T1扰相梯度回波序列的研究结果相比，使用ESWAN序列观察到脾铁质沉着结节的发生率更高（72.7%）。脾铁质沉着结节的存在与脾功能亢进的发生一致，且与残余肝功能相关。
