Xiao Cheng-Zuo, Wei Wei, Guo Zhi-Xing, Li Shu-Hong, Zhang Yong-Fa, Wang Jia-Hong, Shi Ming, Guo Rong-Ping
Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat-Sen University, Guangzhou, Guangdong 510060, P.R. China ; State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P.R. China ; Department of General Surgery, Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University, Shenzhen, Guangdong 518100, P.R. China.
Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat-Sen University, Guangzhou, Guangdong 510060, P.R. China ; State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P.R. China.
Oncol Lett. 2015 Nov;10(5):2787-2794. doi: 10.3892/ol.2015.3677. Epub 2015 Sep 3.
The present study aimed to identify the risk factors influencing the survival of patients with hepatocellular carcinoma (HCC) affected by portal vein tumor thrombus (PVTT), following hepatic resection, and to establish a prognostic model. Between March 2001 and May 2008, 234 cases of HCC with PVTT that underwent hepatic resection were randomly divided into experimental or validation groups. The association between the clinicopathological factors and disease-free survival (DFS) and overall survival (OS) was analyzed, and the significant factors involved were used to establish a prognostic model, which was then validated. Tumor rupture, number of tumors and macroscopic vascular invasion were observed to be independent risk factors of DFS and OS. In the prognostic model, the DFS and OS of low-, medium- and high-risk patients in the experimental group were observed to be significantly different, compared to those in the validation group. In conclusion, the present study established a prognostic model for patients with HCC affected by PVTT following hepatectomy, and demonstrated that the model may be used to guide the treatment of these patients and predict their prognosis.
本研究旨在确定影响门静脉癌栓（PVTT）所致肝细胞癌（HCC）患者肝切除术后生存的危险因素，并建立预后模型。2001年3月至2008年5月期间，将234例行肝切除的伴有PVTT的HCC病例随机分为试验组或验证组。分析临床病理因素与无病生存期（DFS）和总生存期（OS）之间的关联，并使用相关显著因素建立预后模型，随后进行验证。观察到肿瘤破裂、肿瘤数量和肉眼血管侵犯是DFS和OS的独立危险因素。在预后模型中，试验组低、中、高危患者的DFS和OS与验证组相比有显著差异。总之，本研究建立了肝切除术后伴有PVTT的HCC患者的预后模型，并证明该模型可用于指导这些患者的治疗并预测其预后。
