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教学机构中临床耳硬化症患者镫骨手术后功能结果的评估

Evaluation of Functional Outcomes after Stapes Surgery in Patients with Clinical Otosclerosis in a Teaching Institution.

作者信息

Souza José Celso Rodriques de, Bento Ricardo Ferreira, Pereira Larissa Vilela, Ikari Liliane, Souza Stephanie Rugeri, Della Torre Ana Adelina Giantomasi, Fonseca Anna Carolina de Oliveira

机构信息

Department of Otolaryngology, Universidade de São Paulo, School of Medicine, São Paulo, São Paulo, Brazil.

Department of Otolaryngology, Universidade de São Paulo, School of Medicine, São Paulo, São Paulo, Brazil ; Department of Otolaryngology, Anchieta Hospital, Brasília, DF, Brazil.

出版信息

Int Arch Otorhinolaryngol. 2016 Jan;20(1):39-42. doi: 10.1055/s-0035-1563540. Epub 2015 Nov 4.

DOI:10.1055/s-0035-1563540
PMID:26722344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4687999/
Abstract

Introduction Otosclerosis is a primary disease of the temporal bone that leads to stapes ankylosis. Hearing loss is the main symptom. Treatment includes surgery, medical treatment, and sound amplification therapy alone or in combination. Objective To evaluate the functional outcomes of patients with clinical diagnosis of otosclerosis undergoing primary stapes surgery in a teaching institution. Method Retrospective descriptive study. Results A total of 210 ears of 163 patients underwent stapes surgery. Of the 163 patients, 116 (71.2%) underwent unilateral surgery and 47 (28.8%) underwent bilateral surgery. Six of the 210 operated ears had obliterative otosclerosis. The average preoperative and postoperative air-bone gap was 32.06 and 4.39 dB, respectively. The mean preoperative and postoperative bone conduction threshold was 23.17 and 19.82 dB, respectively. A total of 184 (87.6%) ears had a residual air-bone gap <10 dB, and 196 (93.3%) had a residual air-bone gap ≤15 dB. Two patients (0.95%) had severe sensorineural hearing loss. Conclusion Stapes surgery showed excellent functional hearing outcomes in this study. This surgery may be performed in educational institutions with the supervision of experienced surgeons.

摘要

引言 耳硬化症是一种导致镫骨固定的颞骨原发性疾病。听力损失是主要症状。治疗方法包括手术、药物治疗以及单独或联合使用听力放大疗法。目的 评估在一家教学机构中接受初次镫骨手术的临床诊断为耳硬化症患者的功能结局。方法 回顾性描述性研究。结果 163例患者共210耳接受了镫骨手术。在这163例患者中,116例(71.2%)接受了单侧手术,47例(28.8%)接受了双侧手术。210例手术耳中有6例为闭塞性耳硬化症。术前和术后平均气骨导间距分别为32.06和4.39dB。术前和术后平均骨导阈值分别为23.17和19.82dB。共有184耳(87.6%)残余气骨导间距<10dB,196耳(93.3%)残余气骨导间距≤15dB。2例患者(0.95%)出现重度感音神经性听力损失。结论 在本研究中,镫骨手术显示出优异的功能性听力结局。该手术可在有经验的外科医生监督下在教学机构中开展。

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本文引用的文献

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Stapedotomy in cochlear implant candidates with far advanced otosclerosis: a systematic review of the literature and meta-analysis.重度耳硬化症人工耳蜗植入候选者的镫骨切除术:文献系统评价与荟萃分析
Otol Neurotol. 2014 Dec;35(10):1707-14. doi: 10.1097/MAO.0000000000000637.
2
Genetic association analysis in a clinically and histologically confirmed otosclerosis population confirms association with the TGFB1 gene but suggests an association of the RELN gene with a clinically indistinguishable otosclerosis-like phenotype.在经临床和组织学确诊的耳硬化症人群中进行的基因关联分析证实了与转化生长因子β1(TGFB1)基因的关联,但提示RELN基因与临床上难以区分的耳硬化症样表型存在关联。
Otol Neurotol. 2014 Jul;35(6):1058-64. doi: 10.1097/MAO.0000000000000334.
3
Laser versus non-laser stapedotomy in otosclerosis: a systematic review and meta-analysis.耳硬化症中激光与非激光镫骨切除术:系统评价与荟萃分析
Auris Nasus Larynx. 2014 Aug;41(4):337-42. doi: 10.1016/j.anl.2013.12.014. Epub 2014 Feb 23.
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Rare variants in BMP2 and BMP4 found in otosclerosis patients reduce Smad signaling.在耳硬化症患者中发现的BMP2和BMP4中的罕见变异会降低Smad信号传导。
Otol Neurotol. 2014 Mar;35(3):395-400. doi: 10.1097/MAO.0000000000000244.
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