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镫骨切除术的长期听力结果:影响预后因素的分析

Long-term hearing results of stapedotomy: analysis of factors affecting outcome.

作者信息

Dhooge Ingeborg, Desmedt Stéphanie, Maly Thomas, Loose David, Van Hoecke Helen

机构信息

Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.

Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.

出版信息

Eur Arch Otorhinolaryngol. 2018 May;275(5):1111-1119. doi: 10.1007/s00405-018-4899-2. Epub 2018 Feb 16.

Abstract

OBJECTIVE

To evaluate long-term hearing results of stapedotomy and analyze the influence of patient-, disease-, and procedure-related variables.

STUDY DESIGN

Retrospective case series.

SETTING

Tertiary referral center.

PATIENTS

230 ears (202 patients, 10-74 years) underwent stapedotomy for otosclerosis between January 2008 and August 2014. All cases had early postoperative follow-up (4 weeks post-surgery) and 181 cases had late postoperative follow-up (≥ 1 year, average 32.5 months).

INTERVENTION

Stapedotomy procedure for otosclerosis.

MAIN OUTCOME MEASURES

Hearing outcome using conventional audiometry. The primary outcome parameter was the postoperative air-bone gap pure-tone average. Postoperative air-bone gap ≤ 10 dB was defined as surgical success. Preoperative, early postoperative and late postoperative hearing results were compared. Influence of patient- and procedure-related variables on hearing outcome was evaluated by logistic regression analysis.

RESULTS

The postoperative air-bone gap was 10 dB or less in 77.0% of cases early post-surgery and in 70.7% of cases in long-term follow-up. Air-bone gap closure within 20 dB was obtained in 95.7 and 92.3%, respectively. Logistic regression analysis demonstrated that a larger preoperative air-bone gap (p = 0.041) and positive family history of otosclerosis (p = 0.044) were predictive for less surgical success early postoperatively, but not on the long term. Age, gender, primary versus revision surgery, presence of preoperative tinnitus and preoperative vertigo did not independently and significantly influence postoperative air-bone gap closure.

CONCLUSION

Our series confirms excellent hearing results achieved in stapedotomy surgery, also in long-term follow-up. On the long-term no patient-, disease-, or procedure-related variables were identified as predictors of surgical success.

摘要

目的

评估镫骨切除术的长期听力结果,并分析患者、疾病和手术相关变量的影响。

研究设计

回顾性病例系列研究。

研究地点

三级转诊中心。

患者

2008年1月至2014年8月期间,230耳(202例患者,年龄10 - 74岁)因耳硬化症接受了镫骨切除术。所有病例均有术后早期随访(术后4周),181例有术后晚期随访(≥1年,平均32.5个月)。

干预措施

耳硬化症的镫骨切除术。

主要观察指标

采用传统听力测定法评估听力结果。主要结局参数为术后气骨导间距纯音平均值。术后气骨导间距≤10 dB定义为手术成功。比较术前、术后早期和晚期的听力结果。通过逻辑回归分析评估患者和手术相关变量对听力结果的影响。

结果

术后早期77.0%的病例气骨导间距为10 dB或更小,长期随访中这一比例为70.7%。气骨导间距缩小至20 dB以内的比例分别为95.7%和92.3%。逻辑回归分析表明,术前气骨导间距较大(p = 0.041)和耳硬化症家族史阳性(p = 0.044)是术后早期手术成功率较低的预测因素,但长期来看并非如此。年龄、性别、初次手术与翻修手术、术前耳鸣和术前眩晕并未独立且显著影响术后气骨导间距的缩小。

结论

我们的系列研究证实了镫骨切除术即使在长期随访中也能取得优异的听力结果。长期来看,未发现患者、疾病或手术相关变量可作为手术成功的预测因素。

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