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50例老年患者创伤性齿状突骨折后路寰枢椎融合术后的早期发病率和死亡率

Early Morbidity and Mortality in 50 Very Elderly Patients After Posterior Atlantoaxial Fusion for Traumatic Odontoid Fractures.

作者信息

Ryang Yu-Mi, Török Elisabeth, Janssen Insa, Reinke Andreas, Buchmann Niels, Gempt Jens, Ringel Florian, Meyer Bernhard

机构信息

Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

出版信息

World Neurosurg. 2016 Mar;87:381-91. doi: 10.1016/j.wneu.2015.12.026. Epub 2015 Dec 25.

Abstract

BACKGROUND

Traumatic odontoid fractures (tOFs) in the very elderly are associated with high morbidity and mortality. The best treatment strategy (conservative vs. surgery) is still unclear.

METHODS

Between April 2008 and April 2014, fifty (17 male, 33 female) patients (mean age 87.2 ± 4.4 years; range: 80-99) were included in this retrospective cohort study. All patients underwent posterior fusion surgery for tOF. Early outcome, morbidity and mortality, length of hospital and intensive care unit (ICU) stay, comorbidities, and perioperative complications were assessed.

RESULTS

The mean age-adjusted Charlson Comorbidity Index (CCI) was 5.8 ± 3.9 (range: 0-13), and the mean American Society of Anesthesiologists score was 3 ± 0.5 (range: 2-4). Surgery was delayed in 48% of patients. Thirty percent of patients had preoperative complications (72.4% severe), of which a leading cause was dysphagia with subsequent pneumonia, and 18% required preoperative assessment or improvement of health status. Surgery-related complications were experienced in 14% with no neurovascular lesion. Postoperative medical complications occurred in 52% of patients (67.3% severe). Major complications were mostly respiratory/pulmonary (66.7%), of which postoperative pneumonia (36.4%) was leading. Twenty-four percent of patients were ICU monitored. Mean length of ICU stay was 9 ± 6.6 days (1-20). Mean length of hospital stay was 15 ± 8.6 days (4-56). There was no in-hospital mortality, and 30-day mortality was 6%.

CONCLUSIONS

Posterior fusion for tOF in patients 80 years or older seems to be a feasible treatment option in these high-risk patients. Despite a high incidence of severe comorbidities and perioperative complications, outcome was satisfactory.

LEVEL OF EVIDENCE

Our research was a retrospective cohort study, Level III.

摘要

背景

高龄患者的创伤性齿状突骨折(tOFs)与高发病率和死亡率相关。最佳治疗策略(保守治疗与手术治疗)仍不明确。

方法

在2008年4月至2014年4月期间,本回顾性队列研究纳入了50例患者(17例男性,33例女性),平均年龄87.2±4.4岁(范围:80 - 99岁)。所有患者均接受了tOF后路融合手术。评估早期疗效、发病率和死亡率、住院时间和重症监护病房(ICU)停留时间、合并症及围手术期并发症。

结果

年龄调整后的平均查尔森合并症指数(CCI)为5.8±3.9(范围:0 - 13),美国麻醉医师协会平均评分为3±0.5(范围:2 - 4)。48%的患者手术延迟。30%的患者有术前并发症(72.4%为严重并发症),其中主要原因是吞咽困难继发肺炎,18%的患者需要术前评估或改善健康状况。14%的患者发生了与手术相关的并发症,无神经血管损伤。52%的患者发生了术后医疗并发症(67.3%为严重并发症)。主要并发症大多为呼吸/肺部并发症(66.7%),其中术后肺炎(36.4%)最为常见。24%的患者接受了ICU监测。ICU平均停留时间为9±6.6天(1 - 20天)。平均住院时间为15±8.6天(4 - 56天)。无院内死亡,30天死亡率为6%。

结论

对于80岁及以上的tOF患者,后路融合术似乎是这些高危患者可行的治疗选择。尽管严重合并症和围手术期并发症的发生率较高,但疗效令人满意。

证据水平

我们的研究是一项回顾性队列研究,证据水平为III级。

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