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八十岁及以上患者行后路术中脊柱导航下 C1/2 融合术治疗Ⅱ型齿状突骨折的早期并发症、发病率和死亡率。

Early Complications, Morbidity, and Mortality in Octogenarians and Nonagenarians Undergoing Posterior Intra-Operative Spinal Navigation-Based C1/2 Fusion for Type II Odontoid Process Fractures.

机构信息

1 Department of Neurosurgery, Heidelberg University Hospital , Heidelberg, Germany .

2 Department of Neuroradiology, Heidelberg University Hospital , Heidelberg, Germany .

出版信息

J Neurotrauma. 2017 Dec 15;34(24):3326-3335. doi: 10.1089/neu.2017.4968. Epub 2017 Aug 4.

Abstract

Type II odontoid fractures represent the most common cervical spine injury in the elderly. The decision for surgical treatment is still controversial, particularly with regard to the elevated peri-operative risk attributed to frequent comorbidities and poor bone quality. The purpose of this study was to assess both short-term mortality and mid-term clinical and radiological outcome in the elderly. Between January 2007 and December 2015, 35 patients with type II odontoid process fractures who underwent posterior atlanto-axial instrumentation using a modified Goel-Harms technique were retrospectively analyzed and prospectively examined clinically and radiologically. Comorbidities, mortality, and length of intensive care unit (ICU) and hospital stay were determined, as were medical and surgical complications. Quality of life was measured using the EuroQol five dimensions (EQ-5D) and Short Form-36 (SF-36) questionnaires at final follow-up. Average age was 86.5 years. All patients had severe comorbidities pre-operatively. No in-hospital mortality was observed. Average length of hospital stay was 13.8 days and 2.0 days for the ICU. Three patients developed cardiopulmonary complications; one wound infection developed post-operatively. Mean follow-up was 22 months (range, 6-72 months). The quality of life measured by EQ-5D showed a good outcome (0.7 ± 0.1). All SF-36 domains were reduced in comparison to a representative group. Solid bony fusion could be achieved in all patients. Atlanto-axial fusion by using intra-operative spinal navigation is a safe and effective procedure in the elderly, with few complications and preservation of favorable post-operative quality of life. The overall major complication rate was 11%. Surgery in the very old should be considered as first-choice treatment.

摘要

Ⅱ型齿状突骨折是老年人最常见的颈椎损伤。手术治疗的决策仍然存在争议,尤其是考虑到与频繁合并症和骨质量差相关的围手术期风险增加。本研究的目的是评估老年人的短期死亡率和中期临床及影像学结果。2007 年 1 月至 2015 年 12 月,回顾性分析并前瞻性检查了 35 例采用改良 Goel-Harms 技术行后路寰枢椎固定的Ⅱ型齿状突骨折患者。确定了合并症、死亡率以及重症监护病房(ICU)和住院时间的长短,还确定了医疗和手术并发症。使用 EuroQol 五维量表(EQ-5D)和健康调查简表 36 项(SF-36)在最终随访时测量生活质量。平均年龄为 86.5 岁。所有患者术前均有严重的合并症。无院内死亡。平均住院时间为 13.8 天,ICU 为 2.0 天。有 3 例患者发生心肺并发症,1 例术后发生伤口感染。平均随访时间为 22 个月(6-72 个月)。通过 EQ-5D 测量的生活质量显示出良好的结果(0.7±0.1)。与代表性人群相比,所有 SF-36 领域的得分均降低。所有患者均实现了牢固的骨性融合。术中使用脊柱导航进行寰枢椎融合是一种安全有效的老年患者治疗方法,并发症少,术后生活质量良好。总体主要并发症发生率为 11%。对于非常高龄的患者,手术应被视为首选治疗方法。

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