Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; NZ Institute for Advanced Study and Allan Wilson Centre for Molecular Ecology & Evolution, Massey University, Auckland 0745, New Zealand.
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand.
J Infect. 2016 Mar;72(3):295-301. doi: 10.1016/j.jinf.2015.12.010. Epub 2015 Dec 24.
We aimed to examine the dynamics of Staphylococcus aureus nasal carriage in healthy adults.
Selected S. aureus strains isolated from weekly nasal swabs obtained from 122 healthy young adults over a 13 week period were spa typed.
The median duration of intermittent carriage was 4 weeks (IQR 2-6) and the median interval between episodes of carriage of different spa types was 3.5 weeks (IQR 2.25-4). 6/19 (32%) Persistent carriers were colonised with more than one spa type during the study, and in two persistent carriers a brief period of mixed colonisation with two spa types was observed. Even when the carriage strain changed, it was very rare for persistent carriers to have a period during which they were culture-negative (only 6/188 (3%) swabs submitted by persistent carriers failed to culture S. aureus).
Our results imply that at least every eight weeks a healthy young adult is exposed to S. aureus sufficient to cause a new episode of carriage among intermittent carriers. Persistent carriers are almost always colonised with S. aureus and over the course of a year there will be at least one replacement of the dominant strain.
我们旨在研究健康成年人中金黄色葡萄球菌鼻腔携带的动态变化。
选择从 122 名健康年轻成年人每周鼻腔拭子中分离出的金黄色葡萄球菌株进行 spa 分型。
间歇性携带的中位数持续时间为 4 周（IQR 2-6），不同 spa 型之间携带的中位数间隔为 3.5 周（IQR 2.25-4）。6/19（32%）持续性携带者在研究期间定植了一种以上的 spa 型，在两名持续性携带者中观察到短暂的两种 spa 型混合定植期。即使携带的菌株发生了变化，持续性携带者也很少有一段时间培养呈阴性（仅 6/188（3%）由持续性携带者提交的拭子未能培养出金黄色葡萄球菌）。
我们的结果表明，健康的年轻人每隔至少八周就会接触到足以引起间歇性携带者新的携带发作的金黄色葡萄球菌。持续性携带者几乎总是定植有金黄色葡萄球菌，并且在一年中至少会有一次主要菌株的更替。
