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PRF-108 和 PRF-110 对猪术后疼痛的长效镇痛作用。

Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs.

机构信息

The Neufeld Cardiac Research Institute and Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

PainReform, c/o Medica VP, Herzeliya, Israel.

出版信息

Pain Ther. 2016 Jun;5(1):29-42. doi: 10.1007/s40122-015-0043-9. Epub 2016 Jan 2.

DOI:10.1007/s40122-015-0043-9
PMID:26724813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4912964/
Abstract

INTRODUCTION

Local anesthetic infusion techniques have been reported to reduce opiate requirements and pain scores following different kinds of surgery, including orthopedic surgery, inguinal hernia, and Cesarean surgery in women.

METHODS

PRF-108 and PRF-110 formulations were applied to the wound space in an incisional model in pigs to test the hypothesis that these formulations have better and longer analgesic effects than the commercially available ropivacaine solution (Naropin(®), AstraZeneca).

RESULTS

The data show significantly better analgesic activity with PRF-108 and PRF-110 compared to ropivacaine. The duration of the analgesic efficacy of PRF-108 and PRF-110 was at least five times longer than that was measured following treatment with ropivacaine. The data further suggest that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for the commercial ropivacaine solution.

CONCLUSION

Assessing the local concentration of PRF compounds and commercially available ropivacaine solution suggests that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for ropivacaine.

FUNDING

PainReform.

摘要

简介

局部麻醉浸润技术已被报道可减少多种手术（包括骨科手术、腹股沟疝和女性剖宫产术）后的阿片类药物需求和疼痛评分。

方法

PRF-108 和 PRF-110 制剂被应用于猪的切口模型中的伤口空间，以检验这些制剂比市售的罗哌卡因溶液（Naropin®，阿斯利康）具有更好和更长的镇痛效果的假设。

结果

数据显示 PRF-108 和 PRF-110 与罗哌卡因相比具有显著更好的镇痛活性。PRF-108 和 PRF-110 的镇痛效果持续时间至少比罗哌卡因治疗后的测量时间长五倍。数据进一步表明，PRF-108 和 PRF-110 从注射部位（伤口）的主动清除速度明显比商业罗哌卡因溶液慢。

结论

评估 PRF 化合物的局部浓度和市售的罗哌卡因溶液表明，PRF-108 和 PRF-110 从注射部位（伤口）的主动清除速度明显比罗哌卡因慢。

资金来源

PainReform。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/0980a454436f/40122_2015_43_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/e36ce23b3004/40122_2015_43_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/10a36dd57905/40122_2015_43_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/ddc677b02260/40122_2015_43_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/2d54317f68ae/40122_2015_43_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/deb26243a1e8/40122_2015_43_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/0980a454436f/40122_2015_43_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/e36ce23b3004/40122_2015_43_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/10a36dd57905/40122_2015_43_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/ddc677b02260/40122_2015_43_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/2d54317f68ae/40122_2015_43_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/deb26243a1e8/40122_2015_43_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2224/4912964/0980a454436f/40122_2015_43_Fig6_HTML.jpg

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J Pain. 2016 Jan;17(1):36-49. doi: 10.1016/j.jpain.2015.09.011. Epub 2015 Oct 9.
2
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Int J Clin Exp Med. 2015 Jun 15;8(6):10213-24. eCollection 2015.
3
Pain management following spinal surgeries: An appraisal of the available options.脊柱手术后的疼痛管理：对现有选择的评估。
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Pain. 2019 Nov;160(11):2473-2486. doi: 10.1097/j.pain.0000000000001648.
4
The effect of local/topical analgesics on incisional pain in a pig model.局部/外用镇痛药对猪模型切口疼痛的影响。
J Pain Res. 2017 Sep 4;10:2169-2175. doi: 10.2147/JPR.S144949. eCollection 2017.
5
Preclinical Pain Research: Can We Do Better?临床前疼痛研究：我们能否做得更好？
Anesthesiology. 2016 Nov;125(5):846-849. doi: 10.1097/ALN.0000000000001340.
J Craniovertebr Junction Spine. 2015 Jul-Sep;6(3):105-10. doi: 10.4103/0974-8237.161589.
4
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10
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BMC Anesthesiol. 2011 Nov 24;11:23. doi: 10.1186/1471-2253-11-23.