滤泡性淋巴瘤中BCL2部分缺失：由持续的BCL2突变解释的一种不寻常免疫组化染色模式
Partial lack of BCL2 in follicular lymphoma: An unusual immunohistochemical staining pattern explained by ongoing BCL2 mutation.
作者信息
van den Brand Michiel, Garcia-Garcia Mar, Mathijssen Janneke J M, Colomo Lluis, Groenen Patricia J T A, Serrano Sergio, van Krieken J Han J M
机构信息
Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Pathology, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain.
出版信息
Pathol Res Pract. 2016 Feb;212(2):148-50. doi: 10.1016/j.prp.2015.12.001. Epub 2015 Dec 9.
Follicular lymphomas are characterized by overexpression of BCL2 which, in the large majority of cases, is due to a t(14;18) translocation which juxtaposes the BCL2 locus to the immunoglobulin heavy chain locus (IGH). Here, we report partial absence of BCL2 immunohistochemical staining in a case of FL, due to a mutation in the part of BCL2 that encodes the epitope for the most frequently used antibody against BCL2. This finding shows that mutations in BCL2 occur in an ongoing process in follicular which can give rise to unusual immunohistochemical staining patterns.
滤泡性淋巴瘤的特征是BCL2过表达，在大多数情况下，这是由于t(14;18)易位所致，该易位使BCL2基因座与免疫球蛋白重链基因座(IGH)并列。在此，我们报告了1例滤泡性淋巴瘤病例中BCL2免疫组化染色部分缺失，这是由于BCL2中编码针对BCL2最常用抗体表位的部分发生了突变。这一发现表明，BCL2突变在滤泡性淋巴瘤的进展过程中会出现，可导致不寻常的免疫组化染色模式。
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