Ge Lin, Liu Xiao-dong
X-Lab for Transmembrane Signaling Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
School of Life Sciences, Tsinghua University, Beijing 100084, China.
Acta Pharmacol Sin. 2016 Jan;37(1):67-74. doi: 10.1038/aps.2015.140.
Electrical resonance, providing selective signal amplification at preferred frequencies, is a unique phenomenon of excitable membranes, which has been observed in the nervous system at the cellular, circuit and system levels. The mechanisms underlying electrical resonance have not been fully elucidated. Prevailing hypotheses attribute the resonance to voltage-gated ion channels on the membrane of single neurons. In this review, we follow this line of thinking to summarize and analyze the biophysical/molecular mechanisms, and also the physiological relevance of channel-mediated electrical resonance.
电共振能够在特定频率下实现选择性信号放大,是可兴奋膜的一种独特现象,已在神经系统的细胞、回路和系统层面被观察到。电共振背后的机制尚未完全阐明。目前流行的假说是将共振归因于单个神经元膜上的电压门控离子通道。在这篇综述中,我们顺着这一思路总结并分析通道介导的电共振的生物物理/分子机制以及生理相关性。