Revin Victor Vasilevich, Pinyaev Sergey Ivanovich, Parchaykina Marina Vladimirovna, Revina Elvira Sergeevna, Maksimov Georgiy Vladimirovich, Kuzmenko Tatyana Pavlovna
Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia.
Department of Biophysics, Moscow State University, Moscow, Russia.
Front Physiol. 2019 Apr 18;10:384. doi: 10.3389/fphys.2019.00384. eCollection 2019.
It has been shown that in the somatic nerve's lipids, both during excitation and transection, changes occur with the composition of individual phospholipids and in phospholipids fatty acids, which changes the phase state of the myelin and nerve fiber axolemma lipid bilayer. A main contribution in the nerve degenerative processes is dependent on the composition phospholipid's fatty acid changes during the activation of both Ca-dependent and Ca-independent phospholipase A forms. At the same time, we studded changes in phosphoinisitol (PI) and diacylglycerol (DAG), which depend on the phosphoinositide cycle function during nerve excitation and degeneration processes. It was found that myelin lipids and nerve fiber axolemmas are involved not only in the functioning of the peripheral nerves, but also the pathological processes underlying deep functional and structural disorders. The effect of resveratrol on regeneration processes in the damaged rat sciatic nerve has also been investigated.
研究表明，在躯体神经的脂质中，无论是在兴奋还是横断过程中，个别磷脂的组成以及磷脂脂肪酸都会发生变化，这会改变髓鞘和神经纤维轴膜脂质双层的相态。神经退行性过程中的主要作用取决于在钙依赖性和非钙依赖性磷脂酶A形式激活过程中磷脂脂肪酸组成的变化。同时，我们研究了磷酸肌醇（PI）和二酰甘油（DAG）的变化，它们取决于神经兴奋和退变过程中的磷酸肌醇循环功能。研究发现，髓鞘脂质和神经纤维轴膜不仅参与外周神经的功能，还参与深层功能和结构紊乱背后的病理过程。还研究了白藜芦醇对受损大鼠坐骨神经再生过程的影响。
