Faculty of Dentistry, McGill University, Montreal, QC, Canada.
College of Dentistry, University of Dammam, Dammam, Saudi Arabia.
J Clin Periodontol. 2016 Feb;43(2):193-203. doi: 10.1111/jcpe.12506. Epub 2016 Feb 23.
Proton pump inhibitors, over-the-counter drugs taken by millions of patients, diminish bone accrual. Accordingly, we hypothesized that these drugs could impair bone healing and implant osseointegration. This study investigated the effect of post-operative systemic administration of omeprazole on bone healing and implant osseointegration in rat tibiae.
In 24 Sprague-Dawley rats, a titanium implant was placed in the left tibia, and a bone defect was created in the right tibia. During the 2 weeks following surgery, 12 rats were treated with omeprazole (5 mg/kg, daily) and the other 12 with saline. Then, after euthanasia, the volume (mm(3) ) of the cortical defect and the percentages of newly formed bone in the defect, were assessed using microcomputed tomography; peri-implant bone volume/tissue volume and bone-implant contact percentage were assessed by histomorphometry.
Omeprazole-treated rats presented larger cortical defects (2.75 ± 0.59 mm(3) , p = 0.003 versus 2.11 ± 0.36 mm(3) ; p = 0.002) and a lower percentage of newly formed bone in the defects (28.62 ± 13.12; 45.89 ± 9.73; p = 0.003) than controls. Omeprazole-treated rats presented lower peri-implant bone volume/tissue volume (14.3 ± 7.3% versus 30.8 ± 11.0%; p < 0.001) and bone-implant contact (23.3 ± 10.8% versus 41.8 ± 13.3%; p < 0.001) than controls.
Systemically administered omeprazole impairs bone healing and implant osseointegration.
质子泵抑制剂是一种被数百万患者服用的非处方药物，会减少骨量积累。因此，我们假设这些药物可能会影响骨愈合和植入物的骨整合。本研究旨在探讨术后系统给予奥美拉唑对大鼠胫骨骨愈合和植入物骨整合的影响。
在 24 只 Sprague-Dawley 大鼠中，将钛植入物置于左侧胫骨，右侧胫骨造成骨缺损。手术后 2 周内，12 只大鼠用奥美拉唑（5mg/kg，每日）治疗，另 12 只大鼠用生理盐水治疗。然后，处死大鼠后，使用微计算机断层扫描评估皮质缺损的体积（mm3）和缺损中新骨的百分比；通过组织形态计量学评估种植体周围骨体积/组织体积和骨-种植体接触百分比。
奥美拉唑治疗组大鼠皮质缺损较大（2.75±0.59mm3，p=0.003 比 2.11±0.36mm3，p=0.002），缺损中新骨形成百分比较低（28.62±13.12%比 45.89±9.73%，p=0.003）。奥美拉唑治疗组大鼠种植体周围骨体积/组织体积（14.3±7.3%比 30.8±11.0%，p<0.001）和骨-种植体接触（23.3±10.8%比 41.8±13.3%，p<0.001）均低于对照组。
系统给予奥美拉唑可损害骨愈合和植入物骨整合。
