Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
J Clin Periodontol. 2018 Dec;45(12):1485-1497. doi: 10.1111/jcpe.13015. Epub 2018 Nov 5.
Selective serotonin reuptake inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing.
On a total of 24 Sprague-Dawley rats, a custom-made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia. Rats were assigned randomly into two groups and received a daily dose of either sertraline (5 mg/kg) or saline. After two weeks, they were euthanized and bone healing and osseointegration were assessed by micro-CT and histology.
Bone formation in bone defects was significantly lower (p < 0.05) in sertraline-treated rats (BV/TV = 20.67 ± 11.98%) compared to the controls (BV/TV = 37.87 ± 9.56%). Furthermore, the percentage of osseointegration was significantly lower (p < 0.05) in sertraline-treated rats (34.40 ± 7.17%) compared to the controls (54.37 ± 8.58%).
Sertraline hinders bone healing and implant osseointegration.
选择性 5-羟色胺再摄取抑制剂（SSRIs）是最常见的抗抑郁药之一。SSRIs 的使用与骨折和钛植入物失败的风险增加有关。本体内研究旨在探讨 SSRIs 对骨整合和骨愈合的影响。
在总共 24 只 Sprague-Dawley 大鼠中，将定制的钛植入物置于左胫骨中，同时在右胫骨中创建单皮质缺损。大鼠被随机分为两组，每天接受舍曲林（5mg/kg）或生理盐水治疗。两周后，处死大鼠并通过 micro-CT 和组织学评估骨愈合和骨整合。
与对照组（BV/TV=37.87±9.56%）相比，舍曲林治疗组（BV/TV=20.67±11.98%）骨缺损中的骨形成明显降低（p<0.05）。此外，舍曲林治疗组的骨整合百分比明显降低（p<0.05）（34.40±7.17%）与对照组（54.37±8.58%）相比。
舍曲林阻碍骨愈合和植入物骨整合。
