Siegel M M, Walter T K, Ablin A R
Pediatrics. 1977 Jul;60(1):38-40.
Fatal measles pneumonia developed in a 7-year-old boy who was in complete remission from acute lymphoblastic leukemia. There was no detectable antibody titer in two specimens taken eight days apart. Measles virus was grown from a lung biopsy taken shortely after hospital admission. Classical measles had been diagnosed in the patient and his siblings nine months previously. Immunosuppressed children who do not develop an antibody rise after a measles infection are at risk of later development of measles giant cell pneumonia. Suggestions are offered for the prevention of this often fatal complication.
一名7岁男孩在急性淋巴细胞白血病完全缓解期发生了致命的麻疹肺炎。相隔8天采集的两份样本中均未检测到抗体滴度。入院后不久采集的肺活检样本培养出了麻疹病毒。9个月前该患者及其兄弟姐妹被诊断为典型麻疹。麻疹感染后未出现抗体升高的免疫抑制儿童有发生后期麻疹巨细胞肺炎的风险。针对预防这种往往致命的并发症提出了建议。