Lewis M J, Cameron A H, Shah K J, Purdham D R, Mann J R
Br Med J. 1978 Feb 11;1(6109):330-1. doi: 10.1136/bmj.1.6109.330.
Four children who had acurate lymphoblastic leukaemia in remission and developed pneumonia were studied. Investigations including electron microscopy and immunofluorescence of lung biopsy material disclosed measles, although there was no clinical evidence of the disease. Despite an identical presentation, two types of illness developed: two children died of giant-cell pneumonia, while the other two developed pneumonia indistinguishable from that associated with methotrexate treatment, recovering when treated with steroids and gammaglobulin. Measles infection is easily overlooked in the absence of rash. The diagnosis may be suggested by clinical and radiological features and confirmed by specific immunofluorescence staining of lung biopsy tissue.
对4名处于缓解期且患急性淋巴细胞白血病并罹患肺炎的儿童进行了研究。包括对肺活检材料进行电子显微镜检查和免疫荧光检查在内的调查显示为麻疹感染，尽管并无该疾病的临床证据。尽管表现相同，但出现了两种类型的病症：两名儿童死于巨细胞肺炎，而另外两名儿童所患肺炎与甲氨蝶呤治疗相关的肺炎难以区分，在接受类固醇和丙种球蛋白治疗后康复。在没有皮疹的情况下，麻疹感染很容易被忽视。临床和放射学特征可能提示诊断，肺活检组织的特异性免疫荧光染色可确诊。
