铑（I）催化的丙二烯对苯并环丁烯醇 C-C 键的插入反应。
Rh(I)-Catalyzed Insertion of Allenes into C-C Bonds of Benzocyclobutenols.
机构信息
School of Pharmaceutical Sciences and Tsinghua-Peking Joint Centers for Life Science, Tsinghua University , Beijing 100084, China.
出版信息
Org Lett. 2016 Jan 15;18(2):328-31. doi: 10.1021/acs.orglett.5b03518. Epub 2016 Jan 4.
PMID:26727276
Abstract
Herein we report a Rh(I)-catalyzed two carbon insertion into C-C bonds of benzocyclobutenols by employing symmetrical and unsymmetrical allenes. This reaction provides rapid access to alkylidene tetralins bearing two adjacent stereogenic centers in good yields and diasteroselectivities.
摘要
在此，我们报告了一种 Rh(I)催化的苯并环丁烯醇的 C-C 键的两个碳原子插入反应，采用了对称和不对称的丙二烯。该反应以良好的收率和非对映选择性提供了带有两个相邻手性中心的亚烷基四氢萘。
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