He Kang, Geng Chang-An, Cao Tuan-Wu, Wang Hong-Ling, Ma Yun-Bao, Zhang Xue-Mei, Chen Ji-Jun
a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
J Asian Nat Prod Res. 2016 Jun;18(6):528-34. doi: 10.1080/10286020.2015.1116523. Epub 2016 Jan 4.
Two new secoiridoids, swerpatic acid (1) with an unusual C8 skeleton and swerpalactone (2), were isolated along with ten known compounds (3-12) from the whole plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC50 values of 1.96 and 0.50 mM.
从川西獐牙菜全草中分离得到两个新的裂环环烯醚萜类化合物，具有不寻常C8骨架的獐牙菜酸（1）和獐牙菜内酯（2），以及十个已知化合物（3 - 12）。通过综合光谱分析确定了它们的结构。对八个化合物进行了体外抗乙型肝炎病毒（HBV）活性评价，化合物4和10对HBsAg分泌表现出中等抑制活性，IC50值分别为1.96和0.50 mM。
