来自川西獐牙菜的两种新裂环烯醚萜及其他抗乙型肝炎病毒活性成分。
Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens.
作者信息
He Kang, Geng Chang-An, Cao Tuan-Wu, Wang Hong-Ling, Ma Yun-Bao, Zhang Xue-Mei, Chen Ji-Jun
机构信息
a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
出版信息
J Asian Nat Prod Res. 2016 Jun;18(6):528-34. doi: 10.1080/10286020.2015.1116523. Epub 2016 Jan 4.
Two new secoiridoids, swerpatic acid (1) with an unusual C8 skeleton and swerpalactone (2), were isolated along with ten known compounds (3-12) from the whole plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC50 values of 1.96 and 0.50 mM.
从川西獐牙菜全草中分离得到两个新的裂环环烯醚萜类化合物，具有不寻常C8骨架的獐牙菜酸（1）和獐牙菜内酯（2），以及十个已知化合物（3 - 12）。通过综合光谱分析确定了它们的结构。对八个化合物进行了体外抗乙型肝炎病毒（HBV）活性评价，化合物4和10对HBsAg分泌表现出中等抑制活性，IC50值分别为1.96和0.50 mM。
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