Tzanoulinou Stamatina, Sandi Carmen
Department of Fundamental Neurosciences, University of Lausanne, Rue Du Bugnon 9, CH-1005, Lausanne, Switzerland.
Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1050, Lausanne, Switzerland.
Curr Top Behav Neurosci. 2017;30:411-429. doi: 10.1007/7854_2015_430.
The quality and quantity of social experience is fundamental to an individual's health and well-being. Early life stress is known to be an important factor in the programming of the social brain that exerts detrimental effects on social behaviors. The peri-adolescent period, comprising late childhood and adolescence, represents a critical developmental window with regard to the programming effects of stress on the social brain. Here, we discuss social behavior and the physiological and neurobiological consequences of stress during peri-adolescence in the context of rodent paradigms that model human adversity, including social neglect and isolation, social abuse, and exposure to fearful experiences. Furthermore, we discuss peri-adolescent stress as a potent component that influences the social behaviors of individuals in close contact with stressed individuals and that can also influence future generations. We also discuss the temporal dynamics programmed by stress on the social brain and debate whether social behavior alterations are adaptive or maladaptive. By revising the existing literature and defining open questions, we aim to expand the framework in which interactions among peri-adolescent stress, the social brain, and behavior can be better conceptualized.
社会经历的质量和数量对个体的健康和幸福至关重要。已知早期生活压力是社会大脑编程中的一个重要因素，会对社会行为产生不利影响。青春期前后阶段，包括童年晚期和青春期，是压力对社会大脑编程影响的关键发育窗口。在此，我们结合模拟人类逆境的啮齿动物模型，包括社会忽视和隔离、社会虐待以及接触恐惧经历，来讨论青春期前后阶段的社会行为以及压力的生理和神经生物学后果。此外，我们还讨论青春期前后阶段的压力作为一个强大因素，如何影响与受压力个体密切接触的个体的社会行为，以及它如何影响后代。我们还讨论了压力对社会大脑编程的时间动态，并探讨社会行为改变是适应性的还是适应不良的。通过回顾现有文献并确定未解决的问题，我们旨在扩展一个框架，以便能更好地理解青春期前后阶段的压力、社会大脑和行为之间的相互作用。
