Quakyi I A, Otoo L N, Pombo D, Sugars L Y, Menon A, De Groot A S, Johnson A, Alling D, Miller L H, Good M F
National Institutes of Health, Bethesda, Maryland.
Am J Trop Med Hyg. 1989 Aug;41(2):125-34.
Synthetic subunit vaccines to sporozoites, merozoites, and gametes are being developed for malaria. The vaccine strategy assumes that the population to be immunized will respond favorably to these vaccine antigens. Using sera of 35 adults and 50 children from the The Gambia, West Africa, where Plasmodium falciparum is highly endemic, we examined the humoral immune response to candidate malaria vaccine antigens from sporozoites, merozoites, and gametes. We observed widespread restricted immunogenicity to defined parasite antigens in children and adults. HLA typing of adult lymphocytes demonstrated a marked diversity in HLA haplotypes in this population. Our results and those from our studies in mice suggest that genetic factors may partly explain the immunological non-responsiveness. This may necessitate re-evaluation of the malaria vaccine strategy.
正在研发针对疟原虫子孢子、裂殖子和配子的合成亚单位疫苗用于疟疾防治。该疫苗策略假定待免疫人群会对这些疫苗抗原产生良好反应。我们使用了来自西非冈比亚的35名成年人和50名儿童的血清，该地恶性疟原虫高度流行，我们检测了针对来自子孢子、裂殖子和配子的候选疟疾疫苗抗原的体液免疫反应。我们观察到儿童和成人对特定寄生虫抗原普遍存在免疫原性受限的情况。对成人淋巴细胞进行的HLA分型显示该人群中HLA单倍型存在显著多样性。我们的研究结果以及我们在小鼠身上开展的研究结果表明，遗传因素可能部分解释了免疫无反应性。这可能需要重新评估疟疾疫苗策略。
