Tanaka Shigeo
Faculty of Mechanical Engineering, Institute of Science and Engineering, Kanazawa University, Japan.
Clin Calcium. 2016 Jan;26(1):93-8.
Current artificial bones made of metals and ceramics may be replaced around a decade after implantation due to its low durability, which is brought on by a large difference from the host bone in mechanical properties, i.e., low mechano-compatibility. On the other hand, tissue engineering could be a solution with regeneration of bone tissues from stem cells in vitro. However, there are still some problems to realize exactly the same mechanical properties as those of real bone. This paper introduces the technical background of bone tissue engineering and discusses possible methods for installation of mechano-compatibility into a regenerative bone. At the end, future directions toward the realization of ideal mechano-compatible regenerative bone are proposed.
目前由金属和陶瓷制成的人造骨在植入后大约十年可能会被替换，因为其耐久性低，这是由其与宿主骨在机械性能上的巨大差异导致的，即机械兼容性低。另一方面，组织工程可能是一种通过体外干细胞再生骨组织的解决方案。然而，要实现与真实骨骼完全相同的机械性能仍存在一些问题。本文介绍了骨组织工程的技术背景，并讨论了将机械兼容性引入再生骨的可能方法。最后，提出了实现理想机械兼容再生骨的未来方向。
