Shrivats Arun R, McDermott Michael C, Hollinger Jeffrey O
Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Drive, Pittsburgh, PA 15219, USA.
Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Drive, Pittsburgh, PA 15219, USA.
Drug Discov Today. 2014 Jun;19(6):781-6. doi: 10.1016/j.drudis.2014.04.010. Epub 2014 Apr 24.
The quest to surpass the clinical efficacy of the allogeneic bone graft has had limited success, an outcome that is symbolic of tissue engineering as a whole. In this 'State of the Union'-type review, we highlight recent advances in the design of bone regenerative therapeutics using the primary elements of stem cells, growth factors and scaffolds, and identify major obstacles in their paths to the clinic. We underscore the need for rigorous performance criteria in the design of holistic tissue regenerative therapeutics, and an increased emphasis on the product production, storage and handling issues that will ultimately influence clinical success.
超越同种异体骨移植临床疗效的探索取得的成功有限，这一结果是整个组织工程的象征。在这篇“国情咨文”式综述中，我们重点介绍了利用干细胞、生长因子和支架等主要元素设计骨再生疗法的最新进展，并指出了它们进入临床过程中的主要障碍。我们强调，在设计整体组织再生疗法时需要严格的性能标准，并更加重视最终会影响临床成功的产品生产、储存和处理问题。
