2',3',5'-三-O-乙酰基-N₆-(3-羟基苯基)腺苷（WS070117）代谢产物的合成
The Synthesis of the Metabolites of 2',3',5'-Tri-O-acetyl-N₆-(3-hydroxyphenyl) Adenosine (WS070117).
作者信息
Zhang Wen-Xuan, Wu Hong-Na, Li Bo, Wu Hong-Lin, Wang Dong-Mei, Wu Song
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
出版信息
Molecules. 2015 Dec 28;21(1):E8. doi: 10.3390/molecules21010008.
Seven metabolites of 2',3',5'-tri-O-acetyl-N₆-(3-hydroxyphenyl) adenosine (WS070117) were synthesized by deacetylation, hydrolysis, cyclization, sulfonylation and glycosylation reactions, respectively. All these compounds, which could be useful as material standards for metabolic research, were characterized by NMR and HPLC-MS (ESI) analyses.
通过脱乙酰化、水解、环化、磺酰化和糖基化反应分别合成了2',3',5'-三-O-乙酰基-N₆-(3-羟基苯基)腺苷（WS070117）的七种代谢产物。所有这些化合物可用作代谢研究的物质标准品，通过核磁共振（NMR）和高效液相色谱-质谱联用（ESI）分析对其进行了表征。
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