硝苯地平与地尔硫䓬对过敏性哮喘中乙酰甲胆碱诱发支气管痉挛的不同作用
Differential effects of nifedipine and diltiazem on methacholine-induced bronchospasm in allergic asthma.
作者信息
Ferrari M, Olivieri M, De Gasperi M, Lechi A
机构信息
Institute of Clinica Medica, University of Verona, Italy.
出版信息
Ann Allergy. 1989 Sep;63(3):196-200.
The protective effect of nifedipine and diltiazem on methacholine-induced bronchoconstriction was studied in 12 allergic asthmatic patients. Nifedipine significantly but weakly attenuated airway reactivity to methacholine, whereas no protective effect was shown by diltiazem. We conclude that the two calcium antagonists have different effects on human airways. Furthermore, our results suggest that the action of nifedipine on methacholine-induced bronchospasm is too weak to justify its recommendation as therapy.
在12名过敏性哮喘患者中研究了硝苯地平和地尔硫䓬对乙酰甲胆碱诱发支气管收缩的保护作用。硝苯地平显著但微弱地减弱了气道对乙酰甲胆碱的反应性，而地尔硫䓬未显示出保护作用。我们得出结论，这两种钙拮抗剂对人体气道有不同作用。此外，我们的结果表明，硝苯地平对乙酰甲胆碱诱发的支气管痉挛的作用太弱，不足以推荐将其作为治疗药物。
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