海洋来源的n-3脂肪酸对脂肪组织代谢和功能的影响。
The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function.
作者信息
Todorčević Marijana, Hodson Leanne
机构信息
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, OX3 7LE Oxford, UK.
出版信息
J Clin Med. 2015 Dec 31;5(1):3. doi: 10.3390/jcm5010003.
Abstract
Adipose tissue function is key determinant of metabolic health, with specific nutrients being suggested to play a role in tissue metabolism. One such group of nutrients are the n-3 fatty acids, specifically eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3). Results from studies where human, animal and cellular models have been utilised to investigate the effects of EPA and/or DHA on white adipose tissue/adipocytes suggest anti-obesity and anti-inflammatory effects. We review here evidence for these effects, specifically focusing on studies that provide some insight into metabolic pathways or processes. Of note, limited work has been undertaken investigating the effects of EPA and DHA on white adipose tissue in humans whilst more work has been undertaken using animal and cellular models. Taken together it would appear that EPA and DHA have a positive effect on lowering lipogenesis, increasing lipolysis and decreasing inflammation, all of which would be beneficial for adipose tissue biology. What remains to be elucidated is the duration and dose required to see a favourable effect of EPA and DHA in vivo in humans, across a range of adiposity.
摘要
脂肪组织功能是代谢健康的关键决定因素，特定营养素被认为在组织代谢中发挥作用。其中一类营养素是n-3脂肪酸，特别是二十碳五烯酸（EPA；20:5n-3）和二十二碳六烯酸（DHA；22:6n-3）。利用人类、动物和细胞模型研究EPA和/或DHA对白色脂肪组织/脂肪细胞影响的研究结果表明，它们具有抗肥胖和抗炎作用。我们在此回顾这些作用的证据，特别关注那些对代谢途径或过程有一定见解的研究。值得注意的是，在人类中研究EPA和DHA对白色脂肪组织影响的工作有限，而在动物和细胞模型方面开展的工作更多。综合来看，EPA和DHA似乎对降低脂肪生成、增加脂肪分解和减轻炎症有积极作用，所有这些对脂肪组织生物学都有益。有待阐明的是，在不同肥胖程度的人类体内，要看到EPA和DHA产生有利作用所需的持续时间和剂量。
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