血友病患者合并急性肝炎和亚临床肝病时因子VIII相关抗原的改变。

Modifications of factor VIII related antigen in hemophiliacs with acute hepatitis and sub-clinical liver disease.

作者信息

Sultan Y, Maisonneuve P, Simeon J, Intrator L

出版信息

Scand J Haematol Suppl. 1977;30:16-26. doi: 10.1111/j.1600-0609.1977.tb01513.x.

DOI:10.1111/j.1600-0609.1977.tb01513.x

Abstract

Modifications of Factor VIII related antigen (F, VIII R. A.) were investigated in three hemophilic patients during the course of post transfusion hepatitis. F. VIII R. A. was found to be elevated and correlated with the increase of the S.G.P.T. During the acute phase of the disease the Factor VIII related protein was tested for its ristocetin cofactor activity, its electrophoretic mobility on crossed antigen-antibody electrophoresis and its elution pattern on Sepharose 4B columns; all these properties proved to be abnormal. Liver function tests and F. VIII R. A. were measured in 36 multitransfused hemophiliacs. There was a significant increase of the F. VIII R. A. in the plasma of patients with abnormal liver function tests. Only a few of the multitransfused hemophiliacs had clinical symptoms of hepatitis, although 72% had elevated transaminase levels.

摘要

在三名血友病患者输血后肝炎病程中，对因子VIII相关抗原（F，VIII R.A.）的变化进行了研究。发现F，VIII R.A.升高且与血清谷丙转氨酶（S.G.P.T.）升高相关。在疾病急性期，检测了因子VIII相关蛋白的瑞斯托霉素辅因子活性、其在交叉抗原抗体电泳中的电泳迁移率以及其在琼脂糖4B柱上的洗脱模式；所有这些特性均被证明异常。对36名多次输血的血友病患者进行了肝功能检查和F，VIII R.A.测定。肝功能检查异常的患者血浆中F，VIII R.A.显著升高。尽管72%的多次输血血友病患者转氨酶水平升高，但只有少数患者有肝炎临床症状。