Wong Lilian I L, Reers Alexandra R, Currier Heidi A, Williams Tony D, Cox Michael E, Elliott John E, Beischlag Timothy V
Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
The Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, B.C. V6H 3Z6, Canada.
J Biochem Mol Toxicol. 2016 May;30(5):239-42. doi: 10.1002/jbt.21784. Epub 2016 Jan 5.
The effects of the organic flame retardant 1,2-Dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ-/δ-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the α-/-TBECH and γ-/δ-TBECH mixtures repressed androgen-inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor.
在人LNCaP前列腺癌细胞系中检测了有机阻燃剂1,2 - 二溴 - 4 -（1,2 - 二溴乙基）环己烷（TBECH）对雄激素受体靶基因表达的影响。虽然单独的γ-/δ-TBECH导致前列腺特异性抗原（PSA）mRNA积累显著增加，但α-/-TBECH和γ-/δ-TBECH混合物均抑制人LNCaP细胞中雄激素诱导的PSA mRNA和蛋白质积累。因此，我们推测TBECH的异构体混合物可能作为雄激素受体的部分激动剂。
