携带rmtD1和rmtD2 16S rRNA甲基转移酶基因的多重耐药质粒的完整序列
Complete Sequences of Multidrug Resistance Plasmids Bearing rmtD1 and rmtD2 16S rRNA Methyltransferase Genes.
作者信息
Bueno Maria Fernanda C, Francisco Gabriela R, de Oliveira Garcia Doroti, Doi Yohei
机构信息
Centro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
出版信息
Antimicrob Agents Chemother. 2016 Jan 4;60(3):1928-31. doi: 10.1128/AAC.02562-15.
Abstract
Complete nucleotide sequences were determined for two plasmids bearing rmtD group 16S rRNA methyltransferase genes. pKp64/11 was 78 kb in size, belonged to the IncL/M group, and harbored blaTEM-1b, sul1, qacEΔ1, dfrA22, and rmtD1 across two multidrug resistance regions (MRRs). pKp368/10 was 170 kb in size, belonged to the IncA/C group, and harbored acrB, sul1, qacEΔ1, ant(3″)-Ia, aac(6')-Ib, cat, rmtD2, and blaCTX-M-8 across three MRRs. The rmtD-containing regions shared a conserved motif, suggesting a common origin for the two rmtD alleles.
摘要
测定了携带rmtD 16S rRNA甲基转移酶基因的两个质粒的完整核苷酸序列。pKp64/11大小为78 kb，属于IncL/M组，在两个多药耐药区域（MRR）中携带blaTEM-1b、sul1、qacEΔ1、dfrA22和rmtD1。pKp368/10大小为170 kb，属于IncA/C组，在三个MRR中携带acrB、sul1、qacEΔ1、ant(3″)-Ia、aac(6')-Ib、cat、rmtD2和blaCTX-M-8。含rmtD的区域共享一个保守基序，表明这两个rmtD等位基因有共同起源。
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