Haase A M, Gregersen T, Christensen L A, Agnholt J, Dahlerup J F, Schlageter V, Krogh K
Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Motilis Medica SA, Lausanne, Switzerland.
Neurogastroenterol Motil. 2016 Feb;28(2):217-24. doi: 10.1111/nmo.12713. Epub 2016 Jan 4.
Gastrointestinal (GI) dysmotility may present secondary to inflammatory bowel disease. The main aim of this study was to investigate GI motility in ulcerative colitis (UC) patients during severe disease activity.
Twenty patients with severe UC were studied with a novel telemetric capsule system (3D-Transit) designed for minimally invasive, ambulatory assessment of total and regional GI transit times. Ten patients were available for follow-up during remission. Data were compared to those of 20 healthy subjects (HS).
Total GI transit time was significantly longer in patients with severe UC (median 44.5 h [range 9.9-102.7 h]) than in HS (median 27.6 h [range 9.6-56.4 h]) (p = 0.032). Additionally, during severe UC, transit time was prolonged through the proximal colon (p = 0.003) and there were strong trends toward longer than normal small intestinal transit time (HS: median 4.9 h [range 3.4-8.3 h] vs severe UC patients: median 5.9 h [range 3.9-11.9 h]; p = 0.053) and colorectal transit times (HS: median 18.2 h [range 1.5-43.7] vs severe UC patients: median 34.9 h [range 0.4-90.9 h]; p = 0.056). Our data further indicate that total GI and colorectal transit times may be prolonged in UC during early remission.
CONCLUSIONS & INFERENCES: Total GI transit times are significantly prolonged during severe UC.
胃肠道动力障碍可能继发于炎症性肠病。本研究的主要目的是调查溃疡性结肠炎（UC）患者在疾病严重活动期的胃肠道动力。
采用一种新型遥测胶囊系统（3D-Transit）对20例重度UC患者进行研究，该系统设计用于微创、动态评估全胃肠道和区域胃肠道转运时间。10例患者在缓解期可进行随访。将数据与20名健康受试者（HS）的数据进行比较。
重度UC患者的全胃肠道转运时间（中位数44.5小时[范围9.9-102.7小时]）显著长于HS（中位数27.6小时[范围9.6-56.4小时]）（p = 0.032）。此外，在重度UC期间，近端结肠的转运时间延长（p = 0.003），小肠转运时间和结直肠转运时间有长于正常的强烈趋势（HS：中位数4.9小时[范围3.4-8.3小时] vs重度UC患者：中位数5.9小时[范围3.9-11.9小时]；p = 0.053）以及（HS：中位数18.2小时[范围1.5-43.7] vs重度UC患者：中位数34.9小时[范围0.4-90.9小时]；p = 0.056）。我们的数据进一步表明，UC患者在早期缓解期全胃肠道和结直肠转运时间可能延长。
重度UC期间全胃肠道转运时间显著延长。
