Mukherjee Shatavisa, Sen Sukanta, Biswas Arunava, Barman Tapan Kumar, Tripathi Santanu Kumar
Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India; Department of Pharmacology, NSHM Knowledge Campus, Kolkata-Group of Institutions, Kolkata, West Bengal, India.
Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
Indian J Pharmacol. 2015 Nov-Dec;47(6):657-62. doi: 10.4103/0253-7613.169590.
Despite having better tolerability and a wide range of clinical applications over other antidepressants, selective serotonin reuptake inhibitors (SSRIs) are also known to be associated with serious adverse effects like suicidal ideation on chronic use. The present study had explored the impact of the chronic use of sertraline, an SSRI, on the behavioral changes in Wistar albino rats.
The study was conducted on 30 Wistar albino rats of either sex; divided into five groups. Four groups were subjected to chronic mild stress induced by using various stressors randomly scheduled in a week and continued for a period of 3 weeks. The stressed rodents were subjected to sertraline treatment for 9 weeks in different human therapeutic doses extrapolated to animal doses. Behavioral changes were monitored, assessed, and evaluated throughout the treatment phase with the help of tests such as locomotor activity test, forced swim test, tail suspension test, antianxiety test, and sucrose preference test (SPT).
All tests except SPT, demonstrated significant (P < 0.05) reduction in depressive-like activity in the stressed rodents by the mid-treatment phase, followed by an abrupt onset of the depressive state by the end of the treatment phase. SPT showed a significant (P < 0.05) increase in sucrose consumption throughout the treatment phase.
Behavioral changes following chronic sertraline administration conferred gradual remission of depression state on initial treatment phase, followed by a reversal of effect on chronic use.
尽管选择性5-羟色胺再摄取抑制剂（SSRIs）相较于其他抗抑郁药具有更好的耐受性和广泛的临床应用，但长期使用时也已知会与自杀意念等严重不良反应相关。本研究探讨了长期使用SSRI类药物舍曲林对Wistar白化大鼠行为变化的影响。
本研究以30只Wistar白化大鼠（雌雄不限）为对象，分为五组。四组大鼠通过在一周内随机安排各种应激源诱导慢性轻度应激，并持续3周。对应激的啮齿动物以推算至动物剂量的不同人类治疗剂量给予舍曲林治疗9周。在整个治疗阶段，借助诸如自发活动测试、强迫游泳测试、悬尾测试、抗焦虑测试和蔗糖偏好测试（SPT）等试验监测、评估和评价行为变化。
除SPT外，所有试验均表明，在治疗中期，应激啮齿动物的抑郁样活动显著（P<0.05）降低，而在治疗末期抑郁状态突然出现。SPT显示在整个治疗阶段蔗糖消耗显著（P<0.05）增加。
长期给予舍曲林后的行为变化在初始治疗阶段使抑郁状态逐渐缓解，而长期使用后效果逆转。
