BC Cancer Agency-Centre for the North, 1215 Lethbridge Street, Prince George, BC, Canada V2M7E9.
BC Cancer Agency-Centre for the North, 1215 Lethbridge Street, Prince George, BC, Canada V2M7E9; University of Northern BC 333 University way, Prince George, BC, Canada V2N4Z9.
J Bone Oncol. 2015 Oct 29;4(4):107-9. doi: 10.1016/j.jbo.2015.10.002. eCollection 2015 Dec.
This study assesses the incidence of distal bone metastases in palliative radiotherapy (RT) patients.
All courses of RT for bone metastases from 2007-2011 for patient living in British Columbia (BC) were identified in a provincial RT programme. Treated bone metastases (BoM) were categorized as distal if the BoM was located within or distal to the elbow or knee. Patients were grouped by primary tumour site as breast, lung, prostate gastrointestinal, haematological, melanoma, and other. The incidence of distal bone metastases and associations with primary tumour types were determined.
From 2007 to 2011, 8008 patients were treated with 16,277 courses of RT, of which 425 (3%) were courses of RT for distal BoM. The incidence of distal BoM in decreasing order by primary tumour type was melanoma (5%), haematological (3%), lung (2%), other (2%), prostate (2%), breast (1%) and gastrointestinal (1%). Distal BoM where more commonly identified in the lower extremity (87%, p<0.001). Single fraction RT was used more commonly for distal vs non-distal BoM (66% vs. 49%; p<0.001).
The incidence of distal BoM among patients treated with palliative RT was 3% and most commonly identified in patients with melanoma and haematological malignancies.
本研究评估了姑息性放疗（RT）患者中远端骨转移的发生率。
在一个省级 RT 项目中，确定了 2007-2011 年不列颠哥伦比亚省（BC）所有接受 RT 治疗的骨转移患者的治疗过程。如果骨转移位于肘或膝关节以内或远端，则将其归类为远端骨转移。根据原发肿瘤部位将患者分为乳腺癌、肺癌、前列腺癌、胃肠道癌、血液系统恶性肿瘤、黑色素瘤和其他肿瘤。确定了远端骨转移的发生率及其与原发肿瘤类型的关系。
2007 年至 2011 年，8008 例患者接受了 16277 次 RT 治疗，其中 425 次（3%）为远端骨转移 RT 治疗。按原发肿瘤类型降序排列，远端骨转移的发生率依次为黑色素瘤（5%）、血液系统恶性肿瘤（3%）、肺癌（2%）、其他肿瘤（2%）、前列腺癌（2%）、乳腺癌（1%）和胃肠道癌（1%）。远端骨转移更常见于下肢（87%，p<0.001）。与非远端骨转移相比，远端骨转移更常采用单次分割 RT（66% vs. 49%；p<0.001）。
姑息性 RT 治疗患者中远端骨转移的发生率为 3%，最常见于黑色素瘤和血液系统恶性肿瘤患者。
