Slavík Petr, Kohout Michal, Böhm Stanislav, Eigner Václav, Lhoták Pavel
Department of Organic Chemistry, University of Chemistry and Technology Prague (UCTP), Technicka 5, 166 28, Prague 6, Czech Republic.
Institute of Physics AS CR, v.v.i., Na Slovance 2, 182 21 Prague 8, Czech Republic.
Chem Commun (Camb). 2016 Feb 7;52(11):2366-9. doi: 10.1039/c5cc09388k.
Direct mercuration of calix[4]arene immobilized in the partial cone conformation led to the meta-substituted isomer which was subsequently subjected to Pd-catalysed coupling (C-H activation) with the neighbouring aromatic subunit. Regioselective mercuration thus enabled access to a novel type of inherently chiral calixarenes with a highly distorted cavity potentially applicable to the design of new chiral receptors.
固定在部分锥形构象中的杯[4]芳烃的直接汞化反应生成了间位取代异构体，该异构体随后与相邻的芳族亚基进行钯催化偶联（C-H活化）。区域选择性汞化反应因此能够获得一种新型的固有手性杯芳烃，其具有高度扭曲的空腔，有可能应用于新型手性受体的设计。
