• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多种Nrf2激活剂与羰基钴协同作用在体外和体内诱导血红素加氧酶-1并释放一氧化碳。

Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo.

作者信息

Nikam Aniket, Ollivier Anthony, Rivard Michael, Wilson Jayne Louise, Mebarki Kevin, Martens Thierry, Dubois-Randé Jean-Luc, Motterlini Roberto, Foresti Roberta

机构信息

Equipe 12, Inserm U955 , 8 Rue du Général Sarrail, Créteil, 94000, France.

Faculty of Medicine, University Paris Est Créteil , Créteil, 94000, France.

出版信息

J Med Chem. 2016 Jan 28;59(2):756-62. doi: 10.1021/acs.jmedchem.5b01509. Epub 2016 Jan 15.

DOI:10.1021/acs.jmedchem.5b01509
PMID:26730678
Abstract

The Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection against oxidative stress and cellular damage. We synthesized a series of cobalt-based hybrid molecules (HYCOs) that combine an Nrf2 inducer with a releaser of carbon monoxide (CO), an anti-inflammatory product of HO-1. Two HYCOs markedly increased Nrf2/HO-1 expression, liberated CO and exerted anti-inflammatory activity in vitro. HYCOs also up-regulated tissue HO-1 and delivered CO in blood after administration in vivo, supporting their potential use against inflammatory conditions.

摘要

Nrf2/血红素加氧酶-1（HO-1）轴对氧化应激和细胞损伤具有显著的保护作用。我们合成了一系列钴基杂化分子（HYCOs），它们将Nrf2诱导剂与一氧化碳（CO）释放剂相结合，CO是HO-1的一种抗炎产物。两种HYCOs显著增加了Nrf2/HO-1的表达，释放了CO，并在体外发挥了抗炎活性。HYCOs在体内给药后还上调了组织中的HO-1并在血液中释放了CO，这支持了它们在对抗炎症性疾病方面的潜在用途。

相似文献

1
Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo.多种Nrf2激活剂与羰基钴协同作用在体外和体内诱导血红素加氧酶-1并释放一氧化碳。
J Med Chem. 2016 Jan 28;59(2):756-62. doi: 10.1021/acs.jmedchem.5b01509. Epub 2016 Jan 15.
2
Design and synthesis of new hybrid molecules that activate the transcription factor Nrf2 and simultaneously release carbon monoxide.设计和合成新型杂合分子，激活转录因子 Nrf2 并同时释放一氧化碳。
Chemistry. 2014 Nov 3;20(45):14698-704. doi: 10.1002/chem.201403901. Epub 2014 Sep 15.
3
Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.Nrf2-HO-1 抗氧化轴的小分子激活剂调节 BV2 小胶质细胞中的血红素代谢和炎症。
Pharmacol Res. 2013 Oct;76:132-48. doi: 10.1016/j.phrs.2013.07.010. Epub 2013 Aug 11.
4
Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1.兰索拉唑是一种质子泵抑制剂，通过激活核因子E2相关因子2并氧化kelch样ECH相关蛋白1来诱导血红素加氧酶-1，从而在胃黏膜细胞中介导抗炎作用。
J Pharmacol Exp Ther. 2009 Oct;331(1):255-64. doi: 10.1124/jpet.109.152702. Epub 2009 Jul 23.
5
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling.环（组氨酸-脯氨酸）通过调节 NF-κB 和 Nrf2 信号通路发挥抗炎作用。
Int J Biochem Cell Biol. 2012 Mar;44(3):525-35. doi: 10.1016/j.biocel.2011.12.006. Epub 2011 Dec 14.
6
Therapeutic effects of CO-releaser/Nrf2 activator hybrids (HYCOs) in the treatment of skin wound, psoriasis and multiple sclerosis.CO 释放剂/Nrf2 激活剂杂合体（HYCOs）在皮肤创伤、银屑病和多发性硬化症治疗中的疗效。
Redox Biol. 2020 Jul;34:101521. doi: 10.1016/j.redox.2020.101521. Epub 2020 Apr 1.
7
Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide.牛磺酸氯胺通过上调Nrf2介导的血红素加氧酶-1在小鼠巨噬细胞中的表达来刺激胞葬作用：一氧化碳可能参与其中。
Antioxid Redox Signal. 2015 Jul 10;23(2):163-77. doi: 10.1089/ars.2013.5825.
8
Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress.一氧化碳通过激活蛋白激酶R样内质网激酶诱导血红素加氧酶-1，并抑制内质网应激引发的内皮细胞凋亡。
Circ Res. 2007 Oct 26;101(9):919-27. doi: 10.1161/CIRCRESAHA.107.154781. Epub 2007 Sep 6.
9
The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide.血红素加氧酶-1 的诱导通过其副产物一氧化碳抑制热休克蛋白 90 和人乳腺癌细胞的增殖。
Toxicol Appl Pharmacol. 2014 Jan 1;274(1):55-62. doi: 10.1016/j.taap.2013.10.027. Epub 2013 Nov 6.
10
Akt-dependent heme oxygenase-1 induction by NS-398 in C6 glial cells: a potential role for CO in prevention of oxidative damage from hypoxia.
Neuropharmacology. 2007 Sep;53(4):542-51. doi: 10.1016/j.neuropharm.2007.06.022. Epub 2007 Jul 1.

引用本文的文献

1
Immunomodulatory effects of HYCO-3, a dual action CO-releaser/Nrf2 activator.双作用一氧化碳释放剂/Nrf2激活剂HYCO-3的免疫调节作用
Clin Exp Immunol. 2025 Jan 21;219(1). doi: 10.1093/cei/uxae100.
2
CORM-401, an orally active carbon monoxide-releasing molecule, increases body temperature by activating non-shivering thermogenesis in rats.CORM-401是一种口服活性一氧化碳释放分子，通过激活大鼠的非颤抖性产热来升高体温。
Temperature (Austin). 2022 Apr 26;9(4):310-317. doi: 10.1080/23328940.2022.2061270. eCollection 2022.
3
Trichosanthis Semen Suppresses Lipopolysaccharide-Induced Neuroinflammation by Regulating the NF-κB Signaling Pathway and HO-1 Expression in Microglia.
栝楼子通过调控小胶质细胞 NF-κB 信号通路和 HO-1 的表达抑制脂多糖诱导的神经炎症。
Toxins (Basel). 2021 Dec 14;13(12):898. doi: 10.3390/toxins13120898.
4
"CO in a pill": Towards oral delivery of carbon monoxide for therapeutic applications.“药丸中的 CO”：迈向一氧化碳的口服递送用于治疗应用。
J Control Release. 2021 Oct 10;338:593-609. doi: 10.1016/j.jconrel.2021.08.059. Epub 2021 Sep 2.
5
Exploring the Protective Effects and Mechanism of Crocetin From Saffron Against NAFLD by Network Pharmacology and Experimental Validation.基于网络药理学和实验验证探究藏红花中藏红花素对非酒精性脂肪性肝病的保护作用及机制
Front Med (Lausanne). 2021 Jun 9;8:681391. doi: 10.3389/fmed.2021.681391. eCollection 2021.
6
Dual Carbonic Anhydrase IX/XII Inhibitors and Carbon Monoxide Releasing Molecules Modulate LPS-Mediated Inflammation in Mouse Macrophages.双碳酸酐酶IX/ XII抑制剂和一氧化碳释放分子调节小鼠巨噬细胞中脂多糖介导的炎症。
Antioxidants (Basel). 2021 Jan 5;10(1):56. doi: 10.3390/antiox10010056.
7
Targeting Heme Oxygenase-1 in the Arterial Response to Injury and Disease.靶向血红素加氧酶-1在动脉对损伤和疾病的反应中的作用
Antioxidants (Basel). 2020 Sep 4;9(9):829. doi: 10.3390/antiox9090829.
8
Aging and Progression of Beta-Amyloid Pathology in Alzheimer's Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression.阿尔茨海默病中β-淀粉样蛋白病理学的老化与进展与小胶质细胞血红素加氧酶-1的过表达相关。
Antioxidants (Basel). 2020 Jul 21;9(7):644. doi: 10.3390/antiox9070644.
9
Review of the effects of vitexin in oxidative stress-related diseases.牡荆素在氧化应激相关疾病中的作用综述。
Food Sci Nutr. 2020 Apr 14;8(6):2569-2580. doi: 10.1002/fsn3.1567. eCollection 2020 Jun.
10
Therapeutic effects of CO-releaser/Nrf2 activator hybrids (HYCOs) in the treatment of skin wound, psoriasis and multiple sclerosis.CO 释放剂/Nrf2 激活剂杂合体（HYCOs）在皮肤创伤、银屑病和多发性硬化症治疗中的疗效。
Redox Biol. 2020 Jul;34:101521. doi: 10.1016/j.redox.2020.101521. Epub 2020 Apr 1.