Garriga Rosa, Jurewicz Izabela, Romero Elena, Jarne Carmen, Cebolla Vicente L, Dalton Alan B, Muñoz Edgar
Departamento de Química Física, Universidad de Zaragoza , 50009 Zaragoza, Spain.
Department of Physics, Faculty of Engineering & Physical Sciences, University of Surrey , Guildford GU2 7XH, United Kingdom.
ACS Appl Mater Interfaces. 2016 Jan 27;8(3):1913-21. doi: 10.1021/acsami.5b10077. Epub 2016 Jan 14.
The nanocarrier capabilities of atomically smooth two-dimensional sheets of a biantennary oligoglycine peptide C8H16(-CH2-NH-Gly5)2 (also called tectomers) are demonstrated. We show that the pH-controlled, rapid, and reversible assembly and disassembly of oligoglycine can be effectively used for controlled loading and release of the anticancer drug and fluorescent probe coralyne. The calculated partition coefficient in water is of the same order of magnitude or higher when compared to other nanocarriers such as liposomes and micelles, signifying the tectomer's impressive loading capabilities. Moreover, the loading of guest molecules in tectomers facilitates the protection from rapid photochemically induced degradation. Such efficient, pH-sensitive, stable, and biocompatible nanocarriers are extremely attractive for biosensing, therapeutic, and theranostic applications. Additionally, our results suggest that these planar self-assembled materials can also act as phase-transfer vehicles for hydrophobic cargoes further broadening their biomedical and technological applications.
具有双天线寡甘氨酸肽C8H16(-CH2-NH-Gly5)2（也称为tectomers）的原子级光滑二维薄片的纳米载体能力得到了证明。我们表明，寡甘氨酸的pH控制、快速且可逆的组装和解组装可有效地用于抗癌药物和荧光探针珊瑚灵的可控负载和释放。与脂质体和胶束等其他纳米载体相比，计算得出的在水中的分配系数处于相同数量级或更高，这表明tectomers具有令人印象深刻的负载能力。此外，客体分子在tectomers中的负载有助于防止快速的光化学诱导降解。这种高效、pH敏感、稳定且生物相容的纳米载体对于生物传感、治疗和诊疗应用极具吸引力。此外，我们的结果表明，这些平面自组装材料还可以作为疏水性货物的相转移载体，进一步拓宽其生物医学和技术应用。
