Gott V L, Daggett R L, Young W P
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Ann Thorac Surg. 1989 Sep;48(3 Suppl):S28-30. doi: 10.1016/0003-4975(89)90627-9.
Between April 1963 and January 1966, 86 patients at the University of Wisconsin Hospital underwent aortic or mitral valve replacement, or both, with a carbon-coated, central-hinging, bileaflet valve. A 25-year follow-up has been obtained on 43 of these patients discharged with an aortic prosthesis, 13 patients discharged with a mitral prosthesis, and 2 patients discharged with double prostheses. The mean implantation time was 7.2 years, 9.0 years, and 9.5 years, respectively. The longest aortic valve implantation time was 24.2 years in a patient who had her bileaflet valve prophylactically replaced, and the longest mitral implantation time is 24 years in a patient who is doing well with her original prosthesis. We are not aware of any patient among the approximately 700 receiving this valve around the world who has developed fatigue-failure of the silicone-impregnated Teflon fabric leaflet. This valve has demonstrated unexpected durability and has provided some design and biomaterial concepts that are used in a number of current prosthetic valves.
1963年4月至1966年1月期间，威斯康星大学医院的86例患者接受了主动脉瓣或二尖瓣置换术，或两者同时置换，使用的是一种碳涂层、中央铰链、双叶瓣人工瓣膜。对其中43例植入主动脉瓣人工瓣膜出院的患者、13例植入二尖瓣人工瓣膜出院的患者以及2例植入双瓣人工瓣膜出院的患者进行了25年的随访。平均植入时间分别为7.2年、9.0年和9.5年。接受双叶瓣人工瓣膜预防性置换的患者中，主动脉瓣最长植入时间为24.2年；使用原装人工瓣膜情况良好的患者中，二尖瓣最长植入时间为24年。据我们所知，全球约700例接受这种瓣膜的患者中，没有任何患者出现过硅浸渍聚四氟乙烯织物瓣叶疲劳失效的情况。这种瓣膜表现出了意想不到的耐用性，并提供了一些目前许多人工瓣膜所采用的设计和生物材料理念。
