Phillips Danielle, Choleris Elena, Ervin Kelsy S J, Fureix Carole, Harper Laura, Reynolds Kathryn, Niel Lee, Mason Georgia J
Department of Psychology and Neuroscience Program, University of Guelph, Ontario, Canada.
Department of Animal Husbandry, University of Bristol, Langford, UK.
Behav Brain Res. 2016 Mar 15;301:238-42. doi: 10.1016/j.bbr.2015.12.035. Epub 2015 Dec 28.
Stereotypic behaviour (SB) occurs in certain human disorders (e.g. autism), and animals treated with stimulants or raised in impoverished conditions, including laboratory mice in standard cages. Dysfunctional cortico-basal ganglia pathways have been implicated in these examples, but for cage-induced forms of SB, the relative roles of ventral versus dorsal striatum had not been fully ascertained. Here, we used immunohistochemical staining of FosB and ΔFosB to assess long-term activation within the nucleus accumbens and caudate-putamen of C57BL/6 mice. Housed in typical laboratory cages, these mice spontaneously developed different degrees of route-tracing, bar-mouthing and other forms of SB (spending 0% to over 50% of their active time budgets in this behaviour). The most highly stereotypic mice showed the most elevated FosB/ΔFosB activity in the nucleus accumbens. No such patterns occurred in the caudate-putamen. The cage-induced SB common in standard-housed mice thus involves elevated activity within the ventral striatum, suggesting an aetiology closer to compulsive gambling, eating and drug-seeking than to classic amphetamine stereotypies and other behaviours induced by motor loop over-activation.
刻板行为（SB）出现在某些人类疾病（如自闭症）以及用兴奋剂治疗或饲养在贫困环境中的动物身上，包括标准笼中的实验室小鼠。功能失调的皮质 - 基底神经节通路与这些例子有关，但对于笼养诱导形式的SB，腹侧纹状体与背侧纹状体的相对作用尚未完全确定。在这里，我们使用FosB和ΔFosB的免疫组织化学染色来评估C57BL / 6小鼠伏隔核和尾状核 - 壳核内的长期激活情况。饲养在典型实验室笼子里的这些小鼠自发地出现了不同程度的路线追踪、咬杆和其他形式的SB（在这种行为中花费其活动时间预算的0%至超过50%）。刻板行为最严重的小鼠在伏隔核中显示出最高的FosB /ΔFosB活性。尾状核 - 壳核中未出现这种模式。因此，标准饲养小鼠中常见的笼养诱导型SB涉及腹侧纹状体内活性升高，这表明其病因更接近强迫性赌博、饮食和药物寻求，而不是经典的苯丙胺刻板行为和运动环路过度激活诱导的其他行为。
